Evidence map›Paper›PMID 32490168›Full record

ArticleAdvanced materials technologies2019

High-Precision Stereolithography of Biomicrofluidic Devices.

Alexandra P Kuo, Nirveek Bhattacharjee, Yuan-Sheng Lee, Kurt Castro, Yong Tae Kim, Albert Folch

Open access · greenAbstract read
In one paragraph

Article in Advanced materials technologies, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 114 citations in OpenAlex.

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  16. High-resolution stereolithography: Negative spaces enabled by control of fluid mechanics.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  17. Biomicrofluidics · 2024
    Article
  18. Review: Application of 3D Printing Technology in Soft Robots.3D printing and additive manufacturing · 2024
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Alexandra P KuoDepartment of Bioengineering, University of Washington Seattle, WA 98195, USA.
Nirveek BhattacharjeeDepartment of Bioengineering, University of Washington Seattle, WA 98195, USA.
Yuan-Sheng LeeDepartment of Mechanical Engineering University of Washington, Seattle, WA 98195, USA.
Kurt CastroDepartment of Bioengineering, University of Washington Seattle, WA 98195, USA.
Yong Tae KimDepartment of Bioengineering, University of Washington Seattle, WA 98195, USA.
Albert FolchDepartment of Bioengineering, University of Washington Seattle, WA 98195, USA.
University of Washington · US

Funding

Microfluidic Device to Profile Chemosensitivity in Glioma Slice CulturesR01CA181445 · NCI · UNIVERSITY OF WASHINGTON · PI FOLCH, ALBERT · 2014 to 2025
$5.3M
Multiplexed Microfluidic Gradients for Axon GuidanceR01NS064387 · NINDS · UNIVERSITY OF WASHINGTON · PI FOLCH, ALBERT · 2011 to 2015
$1.6M
NCI NIH HHS R01 CA181445NINDS NIH HHS R01 NS064387
6 · The paper itself

Abstract

Stereolithography (SL) is emerging as an attractive alternative to soft lithography for fabricating microfluidic devices due to its low cost and high design efficiency. Low molecular weight poly(ethylene glycol)diacrylate (MW = 258) (PEG-DA-258) has been used for SL 3D-printing of biocompatible microdevices at submillimeter resolution. However, 3D-printing resins that simultaneously feature high transparency, high biocompatibility, and high resolution are still lacking. It is found that photosensitizer isopropyl thioxanthone can, in a concentration-dependent manner, increase the absorbance of the resin (containing PEG-DA-258 and photoinitator Irgacure-819) by over an order of magnitude. This increase in absorbance allows for SL printing of microdevices at sub pixel resolution with commercially available desktop printers and without compromising transparency or biocompatibility. The assembly-free, rapid (<15 h) 3D-printing of a variety of complex 3D microfluidic devices such as a 3D-fluid router, a passive chaotic micro-mixer, an active micro-mixer with pneumatic microvalves, and high-aspect ratio (37:1) microchannels of single pixel width is demonstrated. These manufacturing capabilities are unavailable in conventional microfluidic rapid prototyping techniques. The low absorption of small hydrophobic molecules and microfluidic labeling of cultured mammalian cells in 3D-printed PEG-DA-258 microdevices is demonstrated, indicating the potential of PEG-DA-based fabrication of cell-based assays, drug discovery, and organ-on-chip platforms.

Indexed as

3D printingmicrofluidicpoly(ethylene glycol)diacrylaterapid prototypingstereolithography

Identifiers

PMID32490168
PMCPMC7266111
OpenAlexW2907551309

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.