Evidence map›Paper›PMID 32490146›Full record

ArticleInternational journal of cardiology. Heart & vasculature2020

Paradoxical low-flow phenotype in hospitalized heart failure with preserved ejection fraction.

Donato Mele, Gabriele Pestelli, Davide Dal Molin, Andrea Fiorencis, Filippo Flamigni, Giovanni Andrea Luisi, Vittorio Smarrazzo, Filippo Trevisan, Roberto Ferrari

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of cardiology. Heart & vasculature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Donato MeleCardiology Unit and LTTA Centre, University of Ferrara, Italy.
Gabriele PestelliCardiology Unit, Morgagni-Pierantoni Hospital, Forlì, Italy.
Davide Dal MolinCardiology Unit and LTTA Centre, University of Ferrara, Italy.
Andrea FiorencisCardiology Unit and LTTA Centre, University of Ferrara, Italy.
Filippo FlamigniCardiology Unit and LTTA Centre, University of Ferrara, Italy.
Giovanni Andrea LuisiCardiology Unit and LTTA Centre, University of Ferrara, Italy.
Vittorio SmarrazzoCardiology Unit and LTTA Centre, University of Ferrara, Italy.
Filippo TrevisanCardiology Unit and LTTA Centre, University of Ferrara, Italy.
Roberto FerrariCardiology Unit and LTTA Centre, University of Ferrara, Italy.
University of Ferrara · ITOspedale G.B. Morgagni - L.Pierantoni · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLow flow (LF) in heart failure with preserved ejection fraction (HFpEF) is a paradox but is associated with worse prognosis. Determinants of LF in HFpEF have not been clarified but their assessment could corroborate recognition and definition of such a paradoxical condition.

methodsA cohort of 193 patients hospitalized with HFpEF was retrospectively studied and divided in a group with LF (N = 45), defined by a left ventricular (LV) stroke volume index (SVI) < 30 ml/m

resultsRVD (OR = 7.4; P < 0.001), atrial fibrillation (AF) during echocardiography (OR = 3.26; P = 0.008), and small LV cavity (OR = 3.81; P = 0.003) were independently associated with LF. After adjusting for age, body mass index, systolic blood pressure, renal function, chronic obstructed pulmonary disease, use of ACE inhibitors/angiotensin receptor blockers, moderate tricuspid regurgitation, RVD), LF was associated with mortality (HR = 3.69; P < 0.001) whereas the combination of the determinants of LF was not.

conclusionParadoxical LF in HFpEF is associated with small LV cavity, AF and RVD. None of the combination of different factors associated with LF could substitute direct assessment of LF status in predicting prognosis in this cohort.

Identifiers

PMID32490146
PMCPMC7262439
OpenAlexW3030760280

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.