Evidence map›Paper›PMID 32490145›Full record

ArticleInternational journal of cardiology. Heart & vasculature2020

Impact of traditional risk factors for the outcomes of atrial fibrillation across race and ethnicity and sex groups.

Timothy Shih, Karina Ledezma, Mark McCauley, Jalees Rehman, William L Galanter, Dawood Darbar

Open access · goldAbstract read
In one paragraph

Article in International journal of cardiology. Heart & vasculature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Emerging Antiarrhythmic Drugs for Atrial Fibrillation.International journal of molecular sciences · 2022
    Review
  4. Observational
  5. Sleep apnea and atrial fibrillation: Update 2020.International journal of cardiology. Heart & vasculature · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Timothy ShihDepartments of Medicine, University of Illinois at Chicago, USA.
Karina LedezmaDepartments of Medicine, University of Illinois at Chicago, USA.
Mark McCauleyDepartments of Medicine, University of Illinois at Chicago, USA.
Jalees RehmanDepartments of Medicine, University of Illinois at Chicago, USA.
William L GalanterDepartments of Medicine, University of Illinois at Chicago, USA.
Dawood DarbarDepartments of Medicine, University of Illinois at Chicago, USA.
University of Illinois Chicago · USJesse Brown VA Medical Center · US

Funding

Myosin Light Chain Dephosphorylation by PPP1R12C Promotes Atrial Hypocontractility and Atrial FibrillationR01HL151508 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MCCAULEY, MARK D · 2020 to 2024
$3.2M
PPP1R12C contributes to myosin light chain de-phosphorylation and atrial hypocontractility in atrial fibrillationK08HL130587 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MCCAULEY, MARK D · 2016 to 2020
$892k
NHLBI NIH HHS K08 HL130587NHLBI NIH HHS R01 HL151508
6 · The paper itself

Abstract

backgroundAlthough traditional risk factors for atrial fibrillation (AF) and its outcomes are established in whites, their role in the pathogenesis of AF across race-ethnicity and both sexes remain unclear. Cohort studies have consistently shown worse AF-related outcomes in these groups. The objective of this study was to determine the role played by race- and sex-specific risk factors in AF outcomes in non-Hispanic blacks (NHBs), Hispanics/Latinos (H/Ls), and non-Hispanic whites (NHWs).

methodsUsing electronic health records (EHR), 3607 patients with an ICD-9 code for AF were identified over a 7-year period. Risk factors were identified from ICD to 9 CM claims data: hypertension (HTN), type 2 diabetes mellitus (T2DM), stroke/transient ischemic attack (TIA), smoking, chronic obstructive pulmonary disease (COPD), coronary artery disease (CAD), peripheral arterial disease (PAD) and obstructive sleep apnea (OSA). Multivariate analysis of variance was used to compare the incidence of AF risk factors.

resultsNHBs and H/Ls with AF experienced more stroke than NHWs (27% and 24% vs. 19% P < 0.01). Females had less HTN (48.4% vs 51.6% [males], P = 0.0002), CAD (47.4% vs 55.7% [males], P = 0.02), and smoking rates (38.2% vs 61.8% [males], P < 0.0001) but higher stroke rates (25.9% [female] vs 21.8% [males], P < 0.0001). Age-adjusted risk factors for stroke varied markedly across race-ethnicity and sex.

conclusionsWe identified differences in risk factors for AF and stroke across race-ethnicity and sex. The findings of our study are hypothesis generating and should be used to direct future studies.

Indexed as

Atrial fibrillationRacial disparitiesRisk factorsSex disparitiesStroke

Identifiers

PMID32490145
PMCPMC7262442
OpenAlexW3032336183

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.