Evidence map›Paper›PMID 32490094›Full record

ArticleData in brief2020

Atrial angiotensin-(1-12)/chymase expression data in patient of heart diseases.

Hao Wang, Jasmina Varagic, Sayaka Nagata, Neal D Kon, Sarfaraz Ahmad, Jessica L VonCannon, Kendra N Wright, Xuming Sun, Dwight Deal, Leanne Groban and 1 more

Open access · goldAbstract read
In one paragraph

Article in Data in brief, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Hao WangDepartment of Anesthesiology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Jasmina VaragicDepartment of Surgery, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Sayaka NagataDepartment of Surgery, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Neal D KonDepartment of Cardiothoracic Surgery, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Sarfaraz AhmadDepartment of Surgery, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Jessica L VonCannonDepartment of Surgery, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Kendra N WrightDepartment of Surgery, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Xuming SunDepartment of Anesthesiology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Dwight DealDepartment of Cardiothoracic Surgery, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Leanne GrobanDepartment of Anesthesiology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Carlos M FerrarioDepartment of Surgery, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Wake Forest University · US

Funding

Vaso-Hormonal Mechanisms in HypertensionP01HL051952 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DELL'ITALIA, LOUIS J. · 1994 to 2019
$34.8M
Interplay Between Estrogen, GPR30 and Chymase/RAS in Diastolic FunctionR01AG033727 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI GROBAN, LEANNE · 2009 to 2017
$2.8M
The conditional GPR30 knockout mouse: a model of female-specific cardiac agingR03AG042758 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI GROBAN, LEANNE · 2012 to 2013
$144k
NHLBI NIH HHS P01 HL051952NIA NIH HHS R01 AG033727NIA NIH HHS R03 AG042758
6 · The paper itself

Abstract

The data presented here are related to the research article entitled "Differential expression of the angiotensin-(1-12) [Ang-(1-12)]/chymase axis in human atrial tissue [1]. We have showed that chymase gene transcripts, chymase activity, and immunoreactive- Ang-(1-12) expression levels were higher in left compared to right atrial tissue, irrespective of cardiac disease. This article presents the echocardiographic characteristics of 111 patients undergoing heart surgery for the correction of valvular heart disease, resistant atrial fibrillation or ischemic heart disease. Left atrial chymase mRNA expression and activity, and left atrial Ang-(1-12) levels were compared between patients with stroke vs. non-stroke, congestive heart failure vs. non-heart failure, and in cardiac surgery patients who had a history of postoperative atrial fibrillation vs. non-atrial fibrillation.

Indexed as

angiotensin-(1-12)angiotensin IIatriachymaseheart diseasehuman

Identifiers

PMID32490094
PMCPMC7256457
OpenAlexW3027947137

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.