ArticleQuantitative imaging in medicine and surgery2020
Contrast-enhanced magnetic resonance (MR) T1 mapping with low-dose gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) is promising in identifying clear cell renal cell carcinoma histopathological grade and differentiating fat-poor angiomyolipoma.
Article in Quantitative imaging in medicine and surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 25 citations in OpenAlex.
- Quantitative MRI for World Health Organisation/International Society of Urological Pathology Grading of Renal Cell Carcinoma: a systematic review and diagnostic meta-analysis.European radiology · 2026Article
- Preoperative synthetic magnetic resonance imaging-based biomarkers for predicting tumor budding of rectal cancer.BMC medical imaging · 2026Article
- Modified clear cell likelihood score and a new CAT score in the assessment of indeterminate small renal masses.Journal of cancer research and clinical oncology · 2026Article
- Advances in renal cancer: diagnosis, treatment, and emerging technologies.La Radiologia medica · 2025Review
- B1 corrected T1 mapping in the differentiation and prediction of breast cancer.Scientific reports · 2025Article
- Can multiparametric MRI clear cell likelihood scores differentiate fat-Poor AML from CcRCC in subcentimeter lesions?Abdominal radiology (New York) · 2025Article
- Identification of benign from malignant small renal tumors: is there a possible role of T1 mapping?Discover oncology · 2025Article
- Visual analysis of emerging topics and trends in contrast agent extravasation research in medical imaging: a bibliometric study using CiteSpace and VOSviewer.Frontiers in medicine · 2025Article
- PRIMERS: Polydopamine Radioimmunotherapy with Image-Guided Monitoring and Enhanced Release System.Pharmaceutics · 2024Article
- T1 mapping-based radiomics in the identification of histological types of lung cancer: a reproducibility and feasibility study.BMC medical imaging · 2024Article
- Potential of quantitative T1 mapping to serve as a novel prognostic predictor of clear cell renal cell carcinoma after nephrectomy.Quantitative imaging in medicine and surgery · 2024Article
- T1 mapping in evaluation of clinicopathologic factors for rectal adenocarcinoma.Abdominal radiology (New York) · 2024Article
- Synthetic MRI in breast cancer: differentiating benign from malignant lesions and predicting immunohistochemical expression status.Scientific reports · 2023Article
- Sequential liquid-based cytology based on exfoliative cells of 18-gauge core needle groove to improve renal mass core needle biopsy yield: a real-world observational study.Quantitative imaging in medicine and surgery · 2023Article
- Application of quantitative T1, T2 and T2* mapping magnetic resonance imaging in cartilage degeneration of the shoulder joint.Scientific reports · 2023Article
- Risk factors for the recurrence of cervical cancer using MR-based T1 mapping: A pilot study.Frontiers in oncology · 2023Article
- Associations between brain volumetry and relaxometry signatures and the Edmonton Frail Scale in frailty.Quantitative imaging in medicine and surgery · 2021Article
- A CT-Based Radiomics Nomogram Integrated With Clinic-Radiological Features for Preoperatively Predicting WHO/ISUP Grade of Clear Cell Renal Cell Carcinoma.Frontiers in oncology · 2021Article
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5 authors at 2 institutions in 1 country.
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Abstract
backgroundThis study aimed to identify clear cell renal cell carcinoma (ccRCC) histopathological grade and differentiate it from fat-poor angiomyolipoma (AML). This was achieved through contrast-enhanced magnetic resonance (MR) T1 mapping with intravenous low-dose gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA).
methodsIn total, 56 consecutive patients received MR scanning between January 2016 and December 2018 using the pre- and post- contrast-enhanced T1 mapping sequences with low-dose Gd-DTPA (0.036 mmol/kg). RCCs were pathologically proven in 40 patients after surgery and graded according to the International Society of Urological Pathology (ISUP) classification system. Ten AMLs were pathologically proven by surgery histopathology and six AMLs were diagnosed by magnetic resonance imaging (MRI). Patients were followed up for more than half a year. The mean T1 values of the renal lesion and ipsilateral normal renal parenchyma were measured before and after Gd-DTPA administration (T1p and T1e). The reduction of T1 value (T1d) and the ratio of its reduction (T1d %) were calculated and compared.
resultsIn 40 ccRCCs, higher-grade [International Society of Urologic Pathology (ISUP) grade 3 and 4] and lower-grade (ISUP grade 1 and 2) ccRCCs were noted in 13 and 27 patients, respectively. The mean T1p was 1,514.8±139.4 ms and the mean T1d was 907.7±193.7 ms in the higher-grade ccRCCs, which were significantly higher than in the lower-grade ccRCCs (T1p =1,251.7±151.5 ms and T1d =648.5±218.2 ms, respectively; P<0.001). Fat-poor AMLs had higher T1p (1,677.3±104.8 ms) and T1e (865.6±251.5 ms) as compared to ccRCCs (P<0.001). Combined T1p + T1d showed the highest area under the curve (AUC) (0.912) in the differentiation of higher-grade ccRCCs from lower-grade ccRCCs (P=0.010). Combined T1p + T1e had the highest AUC (0.956) in the differentiation between ccRCCs and fat-poor AMLs (P=0.010). All T1 mapping metrics could discriminate between normal renal parenchyma and renal lesions (P<0.001). No significant difference was found in the T1p and T1e at different parts of the ipsilateral normal renal parenchyma. Interobserver agreement for quantitative longitudinal relaxation time in the T1 maps was excellent.
conclusionsContrast-enhanced T1 mapping with low-dose Gd-DTPA may provide a more reliable and accurate approach in identifying ccRCCs histopathological grade and differentiating ccRCCs from fat-poor AMLs.
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