ArticleJournal of oral biology and craniofacial research
Effect of Jagged1 on the expression of genes in regulation of osteoblast differentiation and bone mineralization ontology in human dental pulp and periodontal ligament cells.
Article in Journal of oral biology and craniofacial research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 17 citations in OpenAlex.
- Article
- Biomedical engineering approaches for the delivery of JAGGED1 as a potential tissue regenerative therapy.Frontiers in bioengineering and biotechnology · 2023Review
- Molecular mechanism of a novel root-end filling material containing zirconium oxide on the osteogenic/odontogenic differentiation of human osteosarcoma MG-63 cells.Frontiers in bioengineering and biotechnology · 2023Article
- IL-7-Treated Periodontal Ligament Cells Regulate Local Immune Homeostasis by Modulating Treg/Th17 Cell Polarization.Frontiers in medicine · 2022Article
- SUMO1 modification of IGF-1R combining with SNAI2 inhibited osteogenic differentiation of PDLSCs stimulated by high glucose.Stem cell research & therapy · 2021Article
- Context-Specific Osteogenic Potential of Mesenchymal Stem Cells.Biomedicines · 2021Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo define the effect of Jagged1 on the gene expression in osteoblast differentiation, regulation of osteoblast differentiation and regulation of bone mineralization ontology.
methodsHuman dental pulp and periodontal ligament cells were isolated using explant method. Cells were seeded on Jagged1 immobilized surface. The mRNA expression was determined using real-time polymerase chain reaction. Mineral deposition was evaluated using alizarin red s staining. Publicly available database of gene expression profiles (GSE126249 and GSE94989) were downloaded and performed bioinformatic analysis to identify gene expression in osteoblast differentiation and regulation of osteoblast differentiation and mineralization ontology.
resultsBoth human dental pulp cells and human periodontal ligament cells expressed higher Notch target gene (
conclusionJagged1 promote the mRNA expression of several genes in osteoblast differentiation related gene ontology. This could be further employed to identify the mechanism by which Jagged1 promoted osteogenic differentiation in human dental pulp and periodontal ligament cells.
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