ReviewAging and disease2020
Parkinson Disease and Orthostatic Hypotension in the Elderly: Recognition and Management of Risk Factors for Falls.
Review in Aging and disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Effectiveness of Acupuncture in the Treatment of Parkinson's Disease: An Overview of Systematic Reviews.Frontiers in neurology · 2020Pooled it
- Repetitive Transcranial Magnetic Stimulation for Improving Cognitive Function in Patients With Mild Cognitive Impairment: A Systematic Review.Frontiers in aging neuroscience · 2020Pooled it
- EEG-based assessment of sustained attention in geriatric inpatients: a feasibility study.GeroScience · 2026Article
- Stage-dependent clinical burden in hospitalized Parkinson's disease with a positive bedside orthostatic hypotension screen: a retrospective cross-sectional analysis.Frontiers in aging neuroscience · 2026Article
- Studying neurocognitive systems for sustained attention in neurogeriatric patients: protocol of the SENSE-AGE study.Frontiers in aging neuroscience · 2026Article
- Exploring the relationship between orthostatic hypotension and gait in people with Parkinson's disease.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Article
- Relationship between serum PTH, potassium (K+), calcium (Ca2+), blood phosphate (PO4), parathyroid hormone (PTH), albumin (ALB) levels and orthostatic hypotension in hemodialysis patients.Journal of medical biochemistry · 2025Article
- Delayed orthostatic hypotension in Parkinson's disease and in the general ageing population.Age and ageing · 2025Article
- Strategies in Parkinson's Disease Therapeutics - A Need for Synergy of Ayurveda, Small Molecules and Nanoparticles aided Approaches.Current topics in medicinal chemistry · 2025Review
- Identification of potentially causative drugs associated with hypotension: A scoping review.Archiv der Pharmazie · 2025Article
- Relationship of foot pain with the increased risk of falls in patients with Parkinson's disease.Journal of foot and ankle research · 2024Article
- Analysis of fall risk factors and environmental hazards for older adults in Japan: assessing fall situations and locations.Journal of physical therapy science · 2024Article
- Successful ageing is associated with falls among older adults in India: a large population based across-sectional study based on LASI.BMC public health · 2024Article
- Machine-learning model for the prediction of acute orthostatic hypotension after levodopa administration.CNS neuroscience & therapeutics · 2024Article
- Ampreloxetine Versus Droxidopa in Neurogenic Orthostatic Hypotension: A Comparative Review.Cureus · 2023Review
- An Adaptive Pedaling Assistive Device for Asymmetric Torque Assistant in Cycling.Sensors (Basel, Switzerland) · 2023Article
- QEEG Signatures are Associated with Nonmotor Dysfunctions in Parkinson's Disease and Atypical Parkinsonism: An Integrative Analysis.Aging and disease · 2023Article
- Parkinson disease primer, part 2: management of motor and nonmotor symptoms.Canadian family physician Medecin de famille canadien · 2023Article
- The implications of the foot health status in Parkinson patients: A case-control study.International wound journal · 2023Article
- Compliance with National and International Guidelines in the Treatment of Nonmotor Symptoms in Late-Stage Parkinson's Disease.Parkinson's disease · 2023Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Parkinson disease (PD) is often associated with postural instability and gait dysfunction that can increase the risk for falls and associated consequences, including injuries, increased burden on healthcare resources, and reduced quality of life. Patients with PD have nearly twice the risk for falls and associated bone fractures compared with their general population counterparts of similar age. Although the cause of falls in patients with PD may be multifactorial, an often under-recognized factor is neurogenic orthostatic hypotension (nOH). nOH is a sustained decrease in blood pressure upon standing whose symptomology can include dizziness/lightheadedness, weakness, fatigue, and syncope. nOH is due to dysfunction of the autonomic nervous system compensatory response to standing and is a consequence of the neurodegenerative processes of PD. The symptoms associated with orthostatic hypotension (OH)/nOH can increase the risk of falls, and healthcare professionals may not be aware of the real-world clinical effect of nOH, the need for routine screening, or the value of early diagnosis of nOH when treating elderly patients with PD. nOH is easily missed and, importantly, healthcare providers may not realize that there are effective treatments for nOH symptoms that could help lessen the fall risk resulting from the condition. This review discusses the burden of, and key risk factors for, falls among patients with PD, with a focus on practical approaches for the recognition, assessment, and successful management of OH/nOH. In addition, insights are provided as to how fall patterns can suggest fall etiology, thereby influencing the choice of intervention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.