ArticleAging and disease2020
T1-weighted MRI-driven Brain Age Estimation in Alzheimer's Disease and Parkinson's Disease.
Article in Aging and disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 2 of them syntheses that pooled it.
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Who cites it
68 citing papers in PubMed, 2 syntheses or guidelines pooled it, 115 citations in OpenAlex.
- BrainAGE, brain health, and mental disorders: A systematic review.Neuroscience and biobehavioral reviews · 2024Pooled it
- The Effects of Transcranial Direct Current Stimulation (tDCS) on Balance Control in Older Adults: A Systematic Review and Meta-Analysis.Frontiers in aging neuroscience · 2020Pooled it
- Deep learning-based MRI analysis reveals Lewy body co-pathology accelerates brain aging in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Aging beyond diagnosis: the MRI brain age gap across disorders.GeroScience · 2026Review
- [Research progress on intelligent brain age prediction methods in diagnosis of Parkinson's disease].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2026Review
- Brain age gap as biomarker linking cardiovascular diseases genetic susceptibility and causality.iScience · 2026Article
- BrainAgeMS: protocol for a prospective comparative study of brain aging in healthy adults and people with multiple sclerosis.Frontiers in neurology · 2026Observational
- Brain age gap as predictor of disease progression in Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Regulatory Genomic Circuitry of Brain Age by Integrative Functional Genomic Analyses.Genomics, proteomics & bioinformatics · 2025Article
- Brain age gap as a predictive biomarker that links aging, lifestyle, and neuropsychiatric health.Communications medicine · 2025Article
- When Age Is More Than a Number: Acceleration of Brain Aging in Neurodegenerative Diseases.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025Article
- Nanomedicine-Driven Modulation of the Gut-Brain Axis: Innovative Approaches to Managing Chronic Inflammation in Alzheimer's and Parkinson's Disease.International journal of molecular sciences · 2025Review
- Advanced brain aging, selective vulnerability in gray matter, and cognition in Parkinson's disease.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- SAGEFusionNet: An Auxiliary Supervised Graph Neural Network for Brain Age Prediction as a Neurodegenerative Biomarker.Brain sciences · 2025Article
- Regional Brain Aging Disparity Index: Region-Specific Brain Aging State Index for Neurodegenerative Diseases and Chronic Disease Specificity.Bioengineering (Basel, Switzerland) · 2025Article
- Do Transformers and CNNs Learn Different Concepts of Brain Age?Human brain mapping · 2025Article
- Structural and functional whole brain changes in autism spectrum disorder at different age stages.European child & adolescent psychiatry · 2025Article
- Neuropsychiatric symptoms and neuroimaging-based brain age in mild cognitive impairment and early dementia: A multicenter study.Psychiatry and clinical neurosciences · 2025Article
- An Update on Neuroaging on Earth and in Spaceflight.International journal of molecular sciences · 2025Review
- An explainable AI approach for mapping multivariate regional brain age and clinical severity patterns in Alzheimer's disease.Biology methods & protocols · 2025Article
8 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Neuroimaging-driven brain age estimation has introduced a robust (reliable and heritable) biomarker for detecting and monitoring neurodegenerative diseases. Here, we computed and compared brain age in Alzheimer's disease (AD) and Parkinson's disease (PD) patients using an advanced machine learning procedure involving T1-weighted MRI scans and gray matter (GM) and white matter (WM) models. Brain age estimation frameworks were built using 839 healthy individuals and then the brain estimated age difference (Brain-EAD: chronological age subtracted from brain estimated age) was assessed in a large sample of PD patients (n = 160) and AD patients (n = 129), respectively. The mean Brain-EADs for GM were +9.29 ± 6.43 years for AD patients versus +1.50 ± 6.03 years for PD patients. For WM, the mean Brain-EADs were +8.85 ± 6.62 years for AD patients versus +2.47 ± 5.85 years for PD patients. In addition, PD patients showed a significantly higher WM Brain-EAD than GM Brain-EAD. In a direct comparison between PD and AD patients, we observed significantly higher Brain-EAD values in AD patients for both GM and WM. A comparison of the Brain-EAD between PD and AD patients revealed that AD patients may have a significantly "older-appearing" brain than PD patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.