ArticleJRSM cardiovascular disease
Post-exertional increase in first-phase ejection fraction in recreational marathon runners.
Article in JRSM cardiovascular disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Exercise-induced ventricular changes in recreational half-marathon runners compared with marathon/ultramarathon runners.International journal of cardiology. Heart & vasculature · 2026Article
- Association Between First-Phase Left Ventricular Ejection Fraction and Severity of Coronary Artery Stenosis and Changes With Interventional Treatment.Journal of the American Heart Association · 2025Article
- Insult of Ultraendurance Events on Blood Pressure: A Systematic Review and Meta-Analysis.Cureus · 2023Review
- First-Phase Left Ventricular Ejection Fraction as an Early Sign of Left Ventricular Dysfunction in Patients with Stable Coronary Artery Disease.Journal of clinical medicine · 2023Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
objectivesRunning a marathon has been equivocally associated with acute changes in cardiac performance. First-phase ejection fraction is a novel integrated echocardiographic measure of left ventricular contractility and systo-diastolic coupling which has never been studied in the context of physical activity. The aim of this study was to assess first-phase ejection fraction following recreational marathon running along with standard echocardiographic indices of systolic and diastolic function.Design and participants: Runners (n = 25, 17 males), age (mean ± standard deviation) 39 ± 9 years, were assessed before and immediately after a marathon race which was completed in 4 h, 10 min ± 47 min.
main outcome measuresCentral hemodynamics were estimated with applanation tonometry; cardiac performance was assessed using standard M-mode two-dimensional Doppler, tissue-doppler imaging and speckle-tracking echocardiography. First-phase ejection fraction was calculated as the percentage change in left ventricular volume from end-diastole to the time of peak aortic blood flow.
resultsConventional indices of systolic function and cardiac performance were similar pre- and post-race while aortic systolic blood pressure decreased by 9 ± 8 mmHg (
conclusionIn recreational marathon runners, there is a marked increase in first-phase ejection fraction after the race despite no other significant change in cardiac performance or conventional measure of systolic function. More detailed physiological studies are required to elucidate the mechanism of this increase.
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