Evidence map›Paper›PMID 32489525›Full record

ArticleComputational and structural biotechnology journal2020

Determining the unbinding events and conserved motions associated with the pyrazinamide release due to resistance mutations of

Olivier Sheik Amamuddy, Thommas Mutemi Musyoka, Rita Afriyie Boateng, Sophakama Zabo, Özlem Tastan Bishop

Open access · goldAbstract read
In one paragraph

Article in Computational and structural biotechnology journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.4field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. A simplified pyrazinamidase test forJournal of clinical microbiology · 2024
    Article
  4. Revealing SARS-CoV-2 MComputational and structural biotechnology journal · 2024
    Article
  5. Global Analysis ofMolecules (Basel, Switzerland) · 2022
    Article
  6. The Structural Basis ofMolecules (Basel, Switzerland) · 2022
    Article
  7. Article
  8. Force Field Parameters for FeMolecules (Basel, Switzerland) · 2021
    Article
  9. Article
  10. Structural and Genomic Insights Into Pyrazinamide Resistance inFrontiers in molecular biosciences · 2021
    Article
  11. Article
  12. Article
  13. Combining structure and genomics to understand antimicrobial resistance.Computational and structural biotechnology journal · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Olivier Sheik AmamuddyResearch Unit in Bioinformatics (RUBi), Department of Biochemistry and Microbiology, Rhodes University, Grahamstown, South Africa.
Thommas Mutemi MusyokaResearch Unit in Bioinformatics (RUBi), Department of Biochemistry and Microbiology, Rhodes University, Grahamstown, South Africa.
Rita Afriyie BoatengResearch Unit in Bioinformatics (RUBi), Department of Biochemistry and Microbiology, Rhodes University, Grahamstown, South Africa.
Sophakama ZaboResearch Unit in Bioinformatics (RUBi), Department of Biochemistry and Microbiology, Rhodes University, Grahamstown, South Africa.
Özlem Tastan BishopResearch Unit in Bioinformatics (RUBi), Department of Biochemistry and Microbiology, Rhodes University, Grahamstown, South Africa.
Rhodes University · ZA

Funding

H3ABioNet: informatics solutions for H3AfricaU24HG006941 · NHGRI · UNIVERSITY OF CAPE TOWN · PI MULDER, NICOLA · 2017 to 2021
$12.9M
NHGRI NIH HHS U24 HG006941Wellcome Trust
6 · The paper itself

Abstract

Pyrazinamide (PZA) is the only first-line antitubercular drug active against latent

Indexed as

3D, Three-dimensionalACPYPE, AnteChamber Python Parser interfaceAmber force field parametersCHPC, Center for High Performance ComputingCOM, Center of massDrug resistanceDrug unbindingFDA, Food and Drug AdministrationHTMD, High throughput molecular dynamicsINH, IsoniazidMBS, Metal binding siteMCBP, Metal Center Parameter BuilderMD, Molecular dynamicsMDR-TB, Multidrug-resistant tuberculosisMissense mutationsMolecular dynamics simulationsPBC, Periodic boundary conditionsPDB, Protein Data bankPOA, Pyrazinoic acidPZA, PyrazinamidePZase, PyrazinamidaseQM, Quantum MechanicsRIF, RifampicinSGNA, Statistically guided network analysisStatistically guided network analysisTB, TuberculosisVAPOR, Variant Analysis PortalWHO, World Health OrganizationWT, Wild type

Identifiers

PMID32489525
PMCPMC7251373
OpenAlexW3028554623

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.