Evidence map›Paper›PMID 32489524›Full record

ArticleComputational and structural biotechnology journal2020

Predicting gene essentiality in

Tulio L Campos, Pasi K Korhonen, Paul W Sternberg, Robin B Gasser, Neil D Young

Abstract read
In one paragraph

Article in Computational and structural biotechnology journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Genome-Wide Inference of Essential Genes inInternational journal of molecular sciences · 2025
    Article
  3. Article
  4. Analysis ofComputational and structural biotechnology journal · 2024
    Article
  5. Inference of essential genes inComputational and structural biotechnology journal · 2024
    Article
  6. Inference of Essential Genes of the ParasiteInternational journal of molecular sciences · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Journal of biosciences · 2022
    Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tulio L CamposDepartment of Veterinary Biosciences, Melbourne Veterinary School, The University of Melbourne, Parkville, Victoria 3010, Australia.
Pasi K KorhonenDepartment of Veterinary Biosciences, Melbourne Veterinary School, The University of Melbourne, Parkville, Victoria 3010, Australia.
Paul W SternbergDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, United States.
Robin B GasserDepartment of Veterinary Biosciences, Melbourne Veterinary School, The University of Melbourne, Parkville, Victoria 3010, Australia.
Neil D YoungDepartment of Veterinary Biosciences, Melbourne Veterinary School, The University of Melbourne, Parkville, Victoria 3010, Australia.

Funding

WormBase: a core data resource for C. elegans and other nematodesU24HG002223 · NHGRI · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI TIM SCHEDL, PAUL Warren STERNBERG · 2018 to 2026
$18.9M
NHGRI NIH HHS U24 HG002223
6 · The paper itself

Abstract

Defining genes that are essential for life has major implications for understanding critical biological processes and mechanisms. Although essential genes have been identified and characterised experimentally using functional genomic tools, it is challenging to predict with confidence such genes from molecular and phenomic data sets using computational methods. Using extensive data sets available for the model organism

Indexed as

Caenorhabditis elegansCDS, coding sequenceCRISPR, Clustered Regularly Interspaced Short Palindromic RepeatsES, Essentiality ScoreEssential genesEssentiality predictionsEST, expressed sequence tagGBM, Gradient Boosting MethodGFF, general feature formatGLM, Generalised Linear ModelGO, gene ontologyMachine-learningML, machine-learningNN, Artificial Neural NetworkPPI, protein-protein interactionPR-AUC, Area Under the Precision-Recall CurveRF, Random ForestRNAi, RNA interferenceROC-AUC, Area Under the Receiver Operating Characteristic CurveSNP, single nucleotide polymorphismSPLS, Sparse Partial Least SquaresSVM, Support-Vector MachineTEA, Tissue Enrichment Analysis tool (WormBase)TSS, transcription start siteVCF, variant call file

Identifiers

PMID32489524
PMCPMC7251299

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.