ReviewJournal of the Intensive Care Society2020
Heart rate variability: Measurement and emerging use in critical care medicine.
Review in Journal of the Intensive Care Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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Who cites it
61 citing papers in PubMed.
- The Effects of Excessive Arousing Video Gaming on vmHRV During Sleep in Habitual Gamers.Applied psychophysiology and biofeedback · 2026Trial
- A closer look at yoga nidra- early randomized sleep lab investigations.Journal of psychosomatic research · 2023Trial
- The cross-sectional association of cognition with diabetic peripheral and autonomic neuropathy-The GRADE study.Journal of diabetes and its complications · 2021 · on this mapTrial
- Article
- Heart Rate Variability Integrated into a Longitudinal Multimodal Model to Predict Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage.Bioengineering (Basel, Switzerland) · 2026Article
- Associations Between Delayed Cerebral Ischemia in Spontaneous Subarachnoid Hemorrhage and Dysfunction of Autonomic Cardiovascular Modulation Compared to Transcranial Doppler Ultrasound Findings.Diagnostics (Basel, Switzerland) · 2026Article
- Use of a Smartphone-Based App in an Online Behavioral Neuroscience Lab Course.Journal of undergraduate neuroscience education : JUNE : a publication of FUN, Faculty for Undergraduate Neuroscience · 2026Article
- Impact of positive end-expiratory pressure on autonomic nervous system activity and its interaction with cerebrovascular reactivity - an experimental study.Journal of clinical monitoring and computing · 2026Article
- Prediction of neurological outcome after pediatric cardiac arrest using heart rate variability and machine learning.Resuscitation · 2026Article
- Sedation level variability an indicator for mortality in mechanical ventilated critically ill patients: a propensity score-weighted cohort study.Frontiers in medicine · 2026Article
- Modelling brain metabolism with interacting nonautonomous phase oscillators.Frontiers in network physiology · 2026Article
- The intervention effect of caffeine oral tablets on mental fatigue induced by nap deprivation: based on assessments of heart rate variability, cognitive performance and subjective fatigue-a pilot study.Frontiers in public health · 2026Article
- Analysis of heart rate variability in critical septic patients using a smartphone application: a prospective cohort study.Frontiers in medicine · 2026Article
- Continuous Physiologic Markers of Heart Rate Variability Derived From Bedside Electrocardiogram Precede Onset of Acute Respiratory Distress Syndrome: A Physiologic Modeling Study.Critical care explorations · 2025Observational
- Long-Term Continuous Heart Rate Variability Monitoring Over 20 Days for Severe Tetanus: A Case Report.The American journal of case reports · 2025Article
- Heart rate, respiratory rate and airflow variability differences between stable and exacerbating COPD patients.ERJ open research · 2025Article
- Classification of Individuals With COVID-19 and Post-COVID-19 Condition and Healthy Controls Using Heart Rate Variability: Machine Learning Study With a Near-Real-Time Monitoring Component.Journal of medical Internet research · 2025Article
- Breathwork for Chronic Stress and Mental Health: Does Choosing a Specific Technique Matter?Medical sciences (Basel, Switzerland) · 2025Review
- Design and Development of a Machine Learning Model for Predicting ICU Patients' Length of Stay.Cureus · 2025Article
- Scalable Precision Psychiatry With an Objective Measure of Psychological Stress: Prospective Real-World Study.Journal of medical Internet research · 2025Observational
1 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Variation in the time interval between consecutive R wave peaks of the QRS complex has long been recognised. Measurement of this RR interval is used to derive heart rate variability. Heart rate variability is thought to reflect modulation of automaticity of the sinus node by the sympathetic and parasympathetic components of the autonomic nervous system. The clinical application of heart rate variability in determining prognosis post myocardial infarction and the risk of sudden cardiac death is well recognised. More recently, analysis of heart rate variability has found utility in predicting foetal deterioration, deterioration due to sepsis and impending multiorgan dysfunction syndrome in critically unwell adults. Moreover, reductions in heart rate variability have been associated with increased mortality in patients admitted to the intensive care unit. It is hypothesised that heart rate variability reflects and quantifies the neural regulation of organ systems such as the cardiovascular and respiratory systems. In disease states, it is thought that there is an 'uncoupling' of organ systems, leading to alterations in 'inter-organ communication' and a clinically detectable reduction in heart rate variability. Despite the increasing evidence of the utility of measuring heart rate variability, there remains debate as to the methodology that best represents clinically relevant outcomes. With continuing advances in technology, our understanding of the physiology responsible for heart rate variability evolves. In this article, we review the current understanding of the physiological basis of heart rate variability and the methods available for its measurement. Finally, we review the emerging use of heart rate variability analysis in intensive care medicine and conditions in which heart rate variability has shown promise as a potential physiomarker of disease.
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