Evidence map›Paper›PMID 32489394›Full record

ArticleNutrition & metabolism2020

Circulating metabolites from the choline pathway and acute coronary syndromes in a Chinese case-control study.

Yuxiang Dai, Qianqian Tian, Jing Si, Zhonghan Sun, Shalaimaiti Shali, Lili Xu, Daoyuan Ren, Shufu Chang, Xin Dong, Hongxia Zhao and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrition & metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 10 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Yuxiang DaiDepartment of Cardiology, Shanghai Institute of Cardiovascular Disease, ZhongShan Hospital, Fudan University, 1609 Xietu Road, Shanghai, 200032 China.
Qianqian TianDepartment of Cardiology, Shanghai Institute of Cardiovascular Disease, ZhongShan Hospital, Fudan University, 1609 Xietu Road, Shanghai, 200032 China.
Jing SiHuman Phenome Institute, Fudan University, 2005 Songhu Road, Shanghai, 200438 China.
Zhonghan SunDepartment of Anthropology and Human Genetics, School of Life Sciences, Fudan University, Shanghai, China.
Shalaimaiti ShaliDepartment of Cardiology, Shanghai Institute of Cardiovascular Disease, ZhongShan Hospital, Fudan University, 1609 Xietu Road, Shanghai, 200032 China.
Lili XuDepartment of Cardiology, Shanghai Institute of Cardiovascular Disease, ZhongShan Hospital, Fudan University, 1609 Xietu Road, Shanghai, 200032 China.
Daoyuan RenDepartment of Cardiology, Shanghai Institute of Cardiovascular Disease, ZhongShan Hospital, Fudan University, 1609 Xietu Road, Shanghai, 200032 China.
Shufu ChangDepartment of Cardiology, Shanghai Institute of Cardiovascular Disease, ZhongShan Hospital, Fudan University, 1609 Xietu Road, Shanghai, 200032 China.
Xin DongDepartment of Cardiology, Shanghai Institute of Cardiovascular Disease, ZhongShan Hospital, Fudan University, 1609 Xietu Road, Shanghai, 200032 China.
Hongxia ZhaoDepartment of Cardiology, Shanghai Institute of Cardiovascular Disease, ZhongShan Hospital, Fudan University, 1609 Xietu Road, Shanghai, 200032 China.
Zhendong MeiDepartment of Anthropology and Human Genetics, School of Life Sciences, Fudan University, Shanghai, China.
Yan ZhengDepartment of Cardiology, Shanghai Institute of Cardiovascular Disease, ZhongShan Hospital, Fudan University, 1609 Xietu Road, Shanghai, 200032 China.
Junbo GeDepartment of Cardiology, Shanghai Institute of Cardiovascular Disease, ZhongShan Hospital, Fudan University, 1609 Xietu Road, Shanghai, 200032 China.
Fudan University · CNShanghai University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAccumulating evidence shows that circulating levels of trimethylamine N-oxide, which is generated from the metabolism of dietary choline, may predict cardiovascular disease among Caucasians. Acute coronary syndrome (ACS), one common presentation of cardiovascular disease, is a spectrum of signs and symptoms due to acute decreased blood flow in the coronary arteries. The relationship between the metabolites from choline pathway and ACS remains unclear. We aimed to assess the associations of circulating metabolites from the choline pathway with ACS among a Chinese population, who consume a different dietary pattern than their Western counterparts.

methodsWe recruited 501 participants who were admitted to the Department of Cardiology, Zhongshan Hospital,Shanghai China between March 2017 and June 2018, including 254 ACS cases and 247 controls. Liquid chromatography-tandem mass spectrometry was used to measure circulating concentrations of metabolites in the choline pathway, including betaine, choline, trimethylamine, and trimethylamine N-oxide. A composite metabolite score using a weighted sum of these four metabolites, and the betaine/choline ratio were calculated. Multivariable logistic regressions were applied to estimate the association of metabolites with ACS, with adjustment of age, sex, body mass index, smoking index, history of diseases, and kidney function.

resultsAfter adjusting for traditional risk factors, per 1-standard deviation (SD) increment in choline was positively associated with the odds of ACS [odds ratio (OR), 95% confidence interval (CI), 1.77(1.44-2.18)], and the other metabolites were not associated with ACS at a statistical significance level. Compared with participants in the lowest quartile of the metabolite score, those in the highest quartile had higher odds of ACS [OR (95% CI), 3.18(1.85-5.54),

conclusionsAmong our Chinese participants, trimethylamine N-oxide was not associated with ACS, while a composite metabolite score of metabolites from the choline pathway was associated with increased odds of ACS. The choline pathway metabolites may be related to the pathophysiology of ACS among Chinese.

Indexed as

Cardiovascular riskCholineIntestinal floraMetabolite scoreTrimethylamine N-oxide

Identifiers

PMID32489394
PMCPMC7245747
OpenAlexW3029382434

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.