Evidence map›Paper›PMID 32489129›Full record

ArticleDrug delivery2020

Hyaluronic acid reduction-sensitive polymeric micelles achieving co-delivery of tumor-targeting paclitaxel/apatinib effectively reverse cancer multidrug resistance.

Xiaoqing Zhang, Xiaomei Ren, Jiayin Tang, Jiangtao Wang, Xiang Zhang, Peng He, Chang Yao, Weihe Bian, Lizhu Sun

Open access · goldAbstract read
In one paragraph

Article in Drug delivery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 35 citations in OpenAlex.

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  11. Targeting Strategies for Enhancing Paclitaxel Specificity in Chemotherapy.Frontiers in cell and developmental biology · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Xiaoqing ZhangDepartment of Mastopathy, The Affiliated Hospital of Nanjing University of Chinese Medicine (Jiangsu Province Hospital of TCM), Nanjing, China.
Xiaomei RenDepartment of Mastopathy, The Affiliated Hospital of Nanjing University of Chinese Medicine (Jiangsu Province Hospital of TCM), Nanjing, China.
Jiayin TangDepartment of Mastopathy, The Affiliated Hospital of Nanjing University of Chinese Medicine (Jiangsu Province Hospital of TCM), Nanjing, China.
Jiangtao WangDepartment of Mastopathy, The Affiliated Hospital of Nanjing University of Chinese Medicine (Jiangsu Province Hospital of TCM), Nanjing, China.
Xiang ZhangThe Department of Oncology, The Affiliated Shuyang Hospital of Xuzhou Medical University, Suqian, China.
Peng HeDepartment of Mastopathy, The Affiliated Hospital of Nanjing University of Chinese Medicine (Jiangsu Province Hospital of TCM), Nanjing, China.
Chang YaoDepartment of Mastopathy, The Affiliated Hospital of Nanjing University of Chinese Medicine (Jiangsu Province Hospital of TCM), Nanjing, China.
Weihe BianDepartment of Mastopathy, The Affiliated Hospital of Nanjing University of Chinese Medicine (Jiangsu Province Hospital of TCM), Nanjing, China.
Lizhu SunThe Department of Oncology, The Affiliated Shuyang Hospital of Xuzhou Medical University, Suqian, China.
Jiangsu Province Hospital · CNNanjing University of Chinese Medicine · CNXuzhou Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multidrug resistance (MDR) of cancer cells is a significant challenge in chemotherapy, highlighting the urgent medical need for simple and reproducible strategies to reverse this process. Here, we report the development of an active tumor-targeting and redox-responsive nanoplatform (PA-ss-NP) using hyaluronic acid-

Indexed as

Drug Resistance, NeoplasmAdjuvants, ImmunologicATP Binding Cassette Transporter, Subfamily BBiological Transport, ActiveDrug Delivery SystemsDrug Resistance, MultipleHumansHyaluronan ReceptorsHyaluronic AcidMembrane Transport ProteinsMicellesPaclitaxelPolymersPyridinesAdjuvants, ImmunologicapatinibATP Binding Cassette Transporter, Subfamily BHyaluronan ReceptorsHyaluronic AcidMembrane Transport ProteinsMicellesPaclitaxelPolymersPyridinesApatinibco-deliverymultidrug resistancepaclitaxeltumor actively targeted

Identifiers

PMID32489129
PMCPMC8216478
OpenAlexW3029530523

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.