ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2020
Sequences of cognitive decline in typical Alzheimer's disease and posterior cortical atrophy estimated using a novel event-based model of disease progression.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- Trends in symptom prevalence and sequential onset of SARS-CoV-2 infection from 2020 to 2022 in East and Southeast Asia: a trajectory pattern exploration based on summary data.Archives of public health = Archives belges de sante publique · 2024Pooled it
- Sequence of episodic memory-related behavioral and brain-imaging abnormalities in type 2 diabetes.Nutrition & diabetes · 2025Trial
- FastEBM: Fast, Scalable, and Uncertainty-Aware Event-Based Disease Progression Modeling.bioRxiv : the preprint server for biology · 2026Article
- Staging and Pseudotime Inference of Alzheimer's Disease Progression using Multimodal Imaging Data.Proceedings. IEEE International Conference on Healthcare Informatics · 2026Article
- Temporal dynamic of cognitive decline in type 2 diabetes mellitus patients: a multimodal biomarker analysis using event-based modal and principal component analysis.Diabetology & metabolic syndrome · 2025Article
- Anterior Insula Drives Progressive Structural Brain Network Atrophy in the Behavioural Variant of Frontotemporal Dementia.Human brain mapping · 2025Article
- Stage-Aware Event-Based Modeling (SA-EBM) for Disease Progression.Proceedings of machine learning research · 2025Article
- Identification of metabolic progression and subtypes in progressive supranuclear palsy by PET molecular imaging.European journal of nuclear medicine and molecular imaging · 2025Article
- The Potential of Disease Progression Modeling to Advance Clinical Development and Decision Making.Clinical pharmacology and therapeutics · 2025Review
- Greater baseline cortical atrophy in the dorsal attention network predicts faster clinical decline in Posterior Cortical Atrophy.Alzheimer's research & therapy · 2024Article
- Greater baseline cortical atrophy in the dorsal attention network predicts faster clinical decline in Posterior Cortical Atrophy.medRxiv : the preprint server for health sciences · 2024Article
- s-SuStaIn: Scaling subtype and stage inference via simultaneous clustering of subjects and biomarkers.Proceedings of machine learning research · 2024Article
- Disentangling sex-dependent effects of APOE on diverse trajectories of cognitive decline in Alzheimer's disease.NeuroImage · 2024Article
- Multimodal subtypes identified in Alzheimer's Disease Neuroimaging Initiative participants by missing-data-enabled subtype and stage inference.Brain communications · 2024Article
- sEBM: Scaling Event Based Models to Predict Disease Progression via Implicit Biomarker Selection and Clustering.Information processing in medical imaging : proceedings of the ... conference · 2023Article
- Exploring the ATN classification system using brain morphology.Alzheimer's research & therapy · 2023Article
- Article
- Deep Learning for Brain MRI Confirms Patterned Pathological Progression in Alzheimer's Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Neurodegenerative disease of the brain: a survey of interdisciplinary approaches.Journal of the Royal Society, Interface · 2023Review
- Event-based modeling in temporal lobe epilepsy demonstrates progressive atrophy from cross-sectional data.Epilepsia · 2022Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
introductionThis work aims to characterize the sequence in which cognitive deficits appear in two dementia syndromes.
methodsEvent-based modeling estimated fine-grained sequences of cognitive decline in clinically-diagnosed posterior cortical atrophy (PCA) (
resultsExperiments revealed differences and similarities in the fine-grained ordering of cognitive decline in PCA (vision first) and tAD (memory first). Simulation experiments reveal that our new model equals or exceeds performance of the classic event-based model, especially for highly non-Gaussian data. DISCUSSION: Our model recovered realistic, phenotypical progression signatures that may be applied in dementia clinical trials for enrichment, and as a data-driven composite cognitive end-point.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.