Evidence map›Paper›PMID 32488937›Full record

ArticleGenes, brain, and behavior2020

Mice lacking paternal expression of imprinted Grb10 are risk-takers.

Claire L Dent, Kira D A Rienecker, Andrew Ward, Jon F Wilkins, Trevor Humby, Anthony R Isles

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, brain, and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Claire L DentBehavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK.
Kira D A RieneckerBehavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK.ORCID 0000-0002-4014-4709
Andrew WardDepartment of Biology and Biochemistry, University of Bath, Bath, UK.
Jon F WilkinsRonin Institute, Montclair, New Jersey, USA.
Trevor HumbyBehavioural Genetics Group, School of Psychology, Cardiff University, Cardiff, UK.
Anthony R IslesBehavioural Genetics Group, MRC Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK.ORCID 0000-0002-7587-5712
Cardiff University · GBRonin Institute · USUniversity of Bath · GB

Funding

Medical Research Council G0801418Medical Research Council MR/L010305/1Medical Research Council MR/S008233/1Wellcome 105218/Z/14/ZWellcome Trust
6 · The paper itself

Abstract

The imprinted genes Grb10 and Nesp influence impulsive behavior on a delay discounting task in an opposite manner. A recently developed theory suggests that this pattern of behavior may be representative of predicted effects of imprinted genes on tolerance to risk. Here we examine whether mice lacking paternal expression of Grb10 show abnormal behavior across a number of measures indicative of risk-taking. Although Grb10

Indexed as

Genomic ImprintingRisk-TakingAnimalsFearFemaleGRB10 Adaptor ProteinMaleMiceMotivationGRB10 Adaptor ProteinGrb10 protein, mouseacoustic startledelay discountingevolutionGrb10imprinted genesmouseNespnovel environmentprogressive ratiorisk-taking

Identifiers

PMID32488937
PMCPMC9393934
OpenAlexW3029749726

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.