ArticleHuman brain mapping2020
Altered resting-state functional connectivity and effective connectivity of the habenula in irritable bowel syndrome: A cross-sectional and machine learning study.
Article in Human brain mapping, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Diagnostic accuracy and quality of artificial intelligence models in irritable bowel syndrome: A systematic review.World journal of gastroenterology · 2025Pooled it
- Effect of Shugan Jianpi Recipe Combined with Cross Moxibustion on Biochemical Examination Indexes and Total Score of TCM Symptoms in Patients with Spleen-Stomach Damp-Heat Diarrhea Irritable Bowel Syndrome.Computational and mathematical methods in medicine · 2022Trial
- Classifying irritable bowel syndrome using spatio-temporal graph convolution networks on brain functional MRI data.Brain communications · 2026Article
- Support vector machine classification of irritable bowel syndrome patients based on whole-brain resting-state functional connectivity features.Quantitative imaging in medicine and surgery · 2024Article
- Long-Term Implicit Epigenetic Stress Information in the Enteric Nervous System and its Contribution to Developing and Perpetuating IBS.Current neuropharmacology · 2024Review
- Altered Brain Functional and Effective Connectivity Induced by Electroacupuncture in Rats Following Anterior Cruciate Ligament Transection.Journal of pain research · 2024Article
- Altered habenular connectivity in chronic low back pain: An fMRI and machine learning study.Human brain mapping · 2023Article
- Abnormal functional connectivity in the habenula is associated with subjective hyperarousal state in chronic insomnia disorder.Frontiers in neurology · 2023Article
- Review
- Functional and effective connectivity analysis of drug-resistant epilepsy: a resting-state fMRI analysis.Frontiers in neuroscience · 2023Article
- Aberrant Cerebello-Thalamo-Cortical Functional and Effective Connectivity in First-Episode Schizophrenia With Auditory Verbal Hallucinations.Schizophrenia bulletin · 2022Article
- Altered effective connectivity within the cingulo-frontal-parietal cognitive attention networks in chronic low back pain: a dynamic causal modeling study.Brain imaging and behavior · 2022Article
- Thalamocortical Mechanisms for Nostalgia-Induced Analgesia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Multi-level variations of lateral habenula in depression: A comprehensive review of current evidence.Frontiers in psychiatry · 2022Review
- The functional connectivity of the basal ganglia subregions changed in mid-aged and young males with chronic prostatitis/chronic pelvic pain syndrome.Frontiers in human neuroscience · 2022Article
- Article
- Altered resting-state functional connectivity and effective connectivity of the habenula in irritable bowel syndrome: A cross-sectional and machine learning study.Human brain mapping · 2020Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Irritable bowel syndrome (IBS) is a disorder involving dysfunctional brain-gut interactions characterized by chronic recurrent abdominal pain, altered bowel habits, and negative emotion. Previous studies have linked the habenula to the pathophysiology of negative emotion and pain. However, no studies to date have investigated habenular function in IBS patients. In this study, we investigated the resting-state functional connectivity (rsFC) and effective connectivity of the habenula in 34 subjects with IBS and 34 healthy controls and assessed the feasibility of differentiating IBS patients from healthy controls using a machine learning method. Our results showed significantly enhanced rsFC of the habenula-left dorsolateral prefrontal cortex (dlPFC) and habenula-periaqueductal grey (PAG, dorsomedial part), as well as decreased rsFC of the habenula-right thalamus (dorsolateral part), in the IBS patients compared with the healthy controls. Habenula-thalamus rsFC was positively correlated with pain intensity (r = .467, p = .005). Dynamic causal modeling (DCM) revealed significantly decreased effective connectivity from the right habenula to the right thalamus in the IBS patients compared to the healthy controls that was negatively correlated with disease duration (r = -.407, p = .017). In addition, IBS was classified with an accuracy of 71.5% based on the rsFC of the habenula-dlPFC, habenula-thalamus, and habenula-PAG in a support vector machine (SVM), which was further validated in an independent cohort of subjects (N = 44, accuracy = 65.2%, p = .026). Taken together, these findings establish altered habenular rsFC and effective connectivity in IBS, which extends our mechanistic understanding of the habenula's role in IBS.
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