Brief Report: Relationship Between Cotinine Levels and Peripheral Endogenous Concentrations of Oxytocin, β-Endorphin, and Orexin in Individuals With Both Alcohol and Nicotine Use Disorders.
Article in The American journal on addictions, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 44% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
8 authors at 4 institutions in 2 countries.
Carolina L Haass-KofflerDepartment of Psychiatry and Human Behavior, Center for Alcohol and Addiction Studies, Brown University, Providence, Rhode Island.ORCID 0000-0002-5634-5679
Roberta PerciballiDepartment of Behavioral and Social Sciences, Center for Alcohol and Addiction Studies, Brown University, Providence, Rhode Island.
Zoe E BrownDepartment of Behavioral and Social Sciences, Center for Alcohol and Addiction Studies, Brown University, Providence, Rhode Island.
Mary R LeeDivision of Intramural Clinical and Biological Research, Clinical Psychoneuroendocrinology and Neuropsychopharmacology Section, National Institute on Drug Abuse Intramural Research Program, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland.
William H ZywiakDepartment of Behavioral and Social Sciences, Center for Alcohol and Addiction Studies, Brown University, Providence, Rhode Island.
Jonathan KurtisDepartment of Pathology and Laboratory Medicine, Brown University, Smithfield, Rhode Island.
Robert M SwiftDepartment of Psychiatry and Human Behavior, Center for Alcohol and Addiction Studies, Brown University, Providence, Rhode Island.
Lorenzo LeggioDepartment of Behavioral and Social Sciences, Center for Alcohol and Addiction Studies, Brown University, Providence, Rhode Island.ORCID 0000-0001-7284-8754
National Institutes of Health · USBrown University · USBryant University · USProvidence College · US
Funding
Clinical Psychoneuroendocrinology and Neuropsychopharmacology (CPN)ZIAAA000218 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI LEGGIO, LORENZO · 2013 to 2020
$22.8M
Using wearables and EMA to examine the links between cannabis and depressionP20GM130414 · NIGMS · BROWN UNIVERSITY · PI Tyler Blake Wray · 2019 to 2026
$22.0M
Clinical Psychoneuroendocrinology and Neuropsychopharmacology (CPN)ZIADA000635 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI LEGGIO, LORENZO · 2020 to 2025
$15.2M
ALCOHOL INTERVENTION/TREATMENT OUTCOME RESEARCH TRAININGT32AA007459 · NIAAA · BROWN UNIVERSITY · PI ROBERT MIRANDA, PETER M. MONTI · 1986 to 2026
$13.3M
Tfh responses to novel vaccine candidates and protection from pediatric falciparum malariaR01AI127699 · NIAID · BROWN UNIVERSITY · PI KURTIS, JONATHAN D. · 2017 to 2021
$3.4M
PfSEA-1 based vaccines for falciparum malariaR01AI110699 · NIAID · RHODE ISLAND HOSPITAL · PI KURTIS, JONATHAN D. · 2014 to 2018
$2.7M
A focus on alpha-1 blockade as a novel pharmacological treatment for alcohol use disorderR01AA027760 · NIAAA · BROWN UNIVERSITY · PI HAASS-KOFFLER, CAROLINA LUISA · 2019 to 2023
$2.6M
One Health Vaccine Development for Bovine and Human SchistosomiasisR01HD092301 · NICHD · BROWN UNIVERSITY · PI KURTIS, JONATHAN D. · 2017 to 2021
$2.5M
Lead optimization of novel CRFBP-CRFR2 complex modulators for alcohol use disorderR01AA026589 · NIAAA · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI SHEFFLER, DOUGLAS J · 2019 to 2021
$2.4M
Mifepristone As A Pharmacological Intervention For Stress-Induced Alcohol DrinkingK01AA023867 · NIAAA · BROWN UNIVERSITY · PI HAASS-KOFFLER, CAROLINA LUISA · 2016 to 2020
$901k
Translational Addiction MedicineZIADA000634 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI LEGGIO, LORENZO · 2020 to 2021
$505k
PfCDPK5 based vaccines for pediatric malariaR21AI131047 · NIAID · BROWN UNIVERSITY · PI RAJ, DIPAK KUMAR · 2018 to 2019
$447k
Division of Intramural Research, National Institute of Allergy and Infectious Diseases R01AI110699Division of Intramural Research, National Institute of Allergy and Infectious Diseases R01AI127699Division of Intramural Research, National Institute of Allergy and Infectious Diseases R01HD092301Division of Intramural Research, National Institute of Allergy and Infectious Diseases R21AI131047Intramural NIH HHS ZIA AA000218NIAAA NIH HHS K01 AA023867NIAAA NIH HHS R01 AA026589NIAAA NIH HHS R01 AA027760NIAAA NIH HHS R03 AA020169NIAAA NIH HHS R21 AA027614NIAAA NIH HHS T32 AA007459NIAID NIH HHS R01 AI110699NIAID NIH HHS R01 AI127699NIAID NIH HHS R21 AI131047NICHD NIH HHS R01 HD092301NIGMS NIH HHS P20 GM130414
6 · The paper itself
Abstract
BACKGROUND AND
objectivesIn this secondary analysis of a pilot clinical trial with individuals with alcohol and nicotine use disorders, we investigate the relationship between serum concentrations of oxytocin, β-endorphin, melatonin, α-melanocyte-stimulating hormone, substance P, and orexin, with objective biomarkers (salivary cotinine and serum γ-glutamyl transferase [GGT]) as well as with self-reported smoking and alcohol drinking.
methodsBiomarkers for a total of N = 19 participants were analyzed using multiplexed, competitive format immune-assay (peptides) and enzyme competitive immunoassay (saliva). A regression analysis using Pearson's correlation coefficient was utilized to determine correlations. We controlled for multiple comparisons, checked for collinearities, and ran two-sided statistical tests.
resultsWe found significant positive correlations for cotinine and oxytocin (P = .002), β-endorphin (P = .008), and orexin (P < .001), but not for either GGT or self-reported smoking or alcohol drinking. CONCLUSION AND SCIENTIFIC SIGNIFICANCE: These preliminary results suggest a relationship between cotinine and oxytocin, β-endorphin, and orexin, which opens up new potential hypotheses on the potential role of these endocrine pathways in tobacco smokers. (Am J Addict 2021;30:88-91).
Indexed as
AdultAlcohol DrinkingAlcoholismalpha-MSHbeta-EndorphinCotinineFemalegamma-GlutamyltransferaseHumansMaleMelatoninMiddle AgedOrexinsOxytocinSalivaSmokingalpha-MSHbeta-EndorphinCotininegamma-GlutamyltransferaseMelatoninOrexinsOxytocinSubstance P
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Brief Report: Relationship Between Cotinine Levels and Peripheral Endogenous Concentrations of Oxytocin, β-Endorphin, and Orexin in Individuals With Both Alcohol and Nicotine Use Disorders. · full record | OpenQuestion