Trial reportPediatric nephrology (Berlin, Germany)2020
Prevalence of acute kidney injury (AKI) in extremely low gestational age neonates (ELGAN).
Trial report in Pediatric nephrology (Berlin, Germany), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 4 syntheses or guidelines pooled it, 91 citations in OpenAlex.
- The global prevalence of acute kidney injury (AKI) in preterm neonates: an epidemiological meta-analysis.European journal of pediatrics · 2026Pooled it
- Growth after pediatric and neonatal acute kidney injury: a meta-analysis.Pediatric nephrology (Berlin, Germany) · 2025Pooled it
- Prevalence and associated factors of acute kidney injury in Ethiopia, systematic review and meta-analysis.Journal of nephrology · 2024Pooled it
- Acute kidney injury in premature and low birth weight neonates: a systematic review and meta-analysis.Pediatric nephrology (Berlin, Germany) · 2022Pooled it
- Elevated serum creatinine over the first week of life and mortality risk in extremely preterm neonates: a secondary analysis of the Preterm Erythropoietin Neuroprotection Trial (PENUT).Pediatric nephrology (Berlin, Germany) · 2026Trial
- Acute Kidney Injury and Neurodevelopmental Outcomes in Extremely Premature Neonates: A Secondary Analysis of a Randomized Clinical Trial.JAMA network open · 2025Trial
- Acute kidney injury and subsequent risk of late-onset infection among extremely low gestational age newborns.Journal of perinatology : official journal of the California Perinatal Association · 2025Trial
- Trial
- Association of delayed cord clamping with acute kidney injury and two-year kidney outcomes in extremely premature neonates: a secondary analysis of the preterm erythropoietin neuroprotection trial (PENUT).Journal of perinatology : official journal of the California Perinatal Association · 2025Trial
- Acute Kidney Injury Defined by Fluid-Corrected Creatinine in Premature Neonates: A Secondary Analysis of the PENUT Randomized Clinical Trial.JAMA network open · 2023Trial
- Association of Fluid Balance With Short- and Long-term Respiratory Outcomes in Extremely Premature Neonates: A Secondary Analysis of a Randomized Clinical Trial.JAMA network open · 2022Trial
- The Impact of Erythropoietin on Short- and Long-Term Kidney-Related Outcomes in Neonates of Extremely Low Gestational Age. Results of a Multicenter, Double-Blind, Placebo-Controlled Randomized Clinical Trial.The Journal of pediatrics · 2021Trial
- Urinary neutrophil gelatinase-associated lipocalin concentration: a baseline study for establishing reference ranges in preterm neonates.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- STARZ Scoring in Very Low Birth Weight (VLBW) neonates: validation and risk-stratification for neonatal acute kidney injury.Pediatric research · 2026Article
- A Pathophysiological Approach for Early Detection and Prevention of AKI in the NICU.American journal of perinatology · 2026Review
- Acute kidney injury and early mortality in extremely preterm neonates born at 22-27 weeks gestation.Pediatric nephrology (Berlin, Germany) · 2026Article
- Perinatal risk factors and 2-year neurodevelopmental outcome of early acute kidney injury in very preterm and very low birth weight infants.Pediatric nephrology (Berlin, Germany) · 2026Article
- Examining the role of biologic sex on kidney outcomes in preterm neonates: A secondary analysis of the PENUT/REPAIReD study.Pediatric nephrology (Berlin, Germany) · 2026Article
- Comparison of creatinine- and cystatin C-based definitions of acute kidney injury in neonates with congenital diaphragmatic hernia.Pediatric nephrology (Berlin, Germany) · 2026Observational
- Efficacy of the STARZ stratification score in determining the risk of acute kidney injury in critically ill neonates.Pediatric nephrology (Berlin, Germany) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundTo determine the prevalence and severity of acute kidney injury (AKI) at different time frames in relation to gestational age (GA) and birthweight (BW) in extremely low gestational age neonates (ELGAN). Our hypothesis is that ELGAN with lower GA and lower BW have higher AKI rates.
methodsA total of 923 ELGAN enrolled in the Preterm Erythropoietin Neuroprotection Trial were evaluated from birth until death or hospital discharge. AKI was defined according to kidney disease: improving global outcomes (KDIGO) definition from clinically-derived serum creatinine (SCr) measurements. Severe AKI was defined as stage 2 or higher.
resultsFor the entire cohort, 351/923 (38.0%, CI = 34.8-41.3%) had at least one episode of stage 1 or higher AKI and 168/923 (18.2%, CI = 15.7-20.7%) had at least one episode of severe (stage 2 or higher) AKI. The prevalence of AKI stage 1 or higher for the entire cohort during the early (days 3-7), middle (days 8-14), and late follow-up period (after day 14) was 112/923 (12.1%, CI = 10.0-14.3%), 142/891 (15.9%, CI = 13.5-18.4%), and 249/875 (28.5%, CI = 25.4-31.5%), respectively. The rates of severe AKI during the hospital course were 27.8%, 21.9%, 13.6%, and 9.4% for the 24-, 25-, 26-, and 27-week GA groups, respectively. AKI rates were significantly higher with decreasing GA and decreasing BW for stated time trends (all p < 0.01 using tests for trend).
conclusionsAKI is relatively common in ELGAN during their initial hospital course and is associated with lower GA and BW.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.