SynthesisHeart failure reviews2022
Diagnostic value of echocardiographic markers for diastolic dysfunction and heart failure with preserved ejection fraction.
Synthesis in Heart failure reviews, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Epidemiology of heart failure in diabetes: a disease in disguise.Diabetologia · 2024Pooled it
- Diagnosis of heart failure with preserved ejection fraction: a systematic narrative review of the evidence.Heart failure reviews · 2024Pooled it
- Natriuretic peptides for the detection of diastolic dysfunction and heart failure with preserved ejection fraction-a systematic review and meta-analysis.BMC medicine · 2020Pooled it
- Unmasking Left Ventricular Diastolic Dysfunction: Pathophysiology, Diagnosis, and Treatment Strategies.Medical sciences (Basel, Switzerland) · 2025Review
- Left atrioventricular coupling index measured by echocardiography in heart failure with preserved ejection fraction.Scientific reports · 2025Article
- Improvement initiatives in the diagnostic process of heart failure: a scoping review.Frontiers in cardiovascular medicine · 2025Review
- Alarin regulates RyR2 and SERCA2 to improve cardiac function in heart failure with preserved ejection fraction.European journal of histochemistry : EJH · 2024Article
- Subtle echocardiogram findings requiring further investigation: restrictive cardiomyopathy in a rare genetic condition.BMJ case reports · 2024Article
- New perspectives in the echocardiographic hemodynamics multiparametric assessment of patients with heart failure.Heart failure reviews · 2024Review
- Left Ventricular and Atrial Deformation in Patients with Acute Decompensated Heart Failure: A Pilot Study.Diagnostics (Basel, Switzerland) · 2024Article
- The Clinical Applications of Left Atrial Strain: A Comprehensive Review.Medicina (Kaunas, Lithuania) · 2024Review
- Novel echocardiographic markers for left ventricular filling pressure prediction in heart failure with preserved ejection fraction (ECHO-PREDICT): a prospective cross-sectional study.Annals of medicine and surgery (2012) · 2023Article
- Feasibility study on evaluating right ventricular diastolic function by new Tei'-Index.Heliyon · 2023Article
- Left atrial longitudinal strain analysis in long Covid-19 syndrome.The international journal of cardiovascular imaging · 2023Article
- Exercise-Induced Pulmonary Hypertension: A Valid Entity or Another Factor of Confusion?Life (Basel, Switzerland) · 2023Review
- Diastolic dysfunction and sex-specific progression to HFpEF: current gaps in knowledge and future directions.BMC medicine · 2022Review
- Association of body mass index with left ventricular diastolic dysfunction among ambulatory individuals with diabetes mellitus in rural Uganda: a cross-sectional study.BMC cardiovascular disorders · 2022Article
- The Value of Echocardiography Combined with NT-pro BNP Level in Assessment and Prognosis of Diastolic Heart Failure.Computational and mathematical methods in medicine · 2022Article
- Association of Hypertensive Intracerebral Hemorrhage with Left Ventricular Hypertrophy on Transthoracic Echocardiography.Journal of clinical medicine · 2020Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to evaluate the diagnostic performance of echocardiographic markers of heart failure with preserved ejection fraction (HFpEF) and left ventricular diastolic dysfunction (LVDD) in comparison with the gold standard of cardiac catheterization. Diagnosing HFpEF is challenging, as symptoms are non-specific and often absent at rest. A clear need exists for sensitive echocardiographic markers to diagnose HFpEF. We systematically searched for studies testing the diagnostic value of novel echocardiographic markers for HFpEF and LVDD. Two investigators independently reviewed the studies and assessed the risk of bias. Results were meta-analysed when four or more studies reported a similar diagnostic measure. Of 353 studies, 20 fulfilled the eligibility criteria. The risk of bias was high especially in the patients' selection domain. The highest diagnostic performance was demonstrated by a multivariable model combining echocardiographic, clinical and arterial function markers with an area under the curve of 0.95 (95% CI, 0.89-0.98). A meta-analysis of four studies indicated a reasonable diagnostic performance for left atrial strain with an AUC of 0.83 (0.70-0.95), a specificity of 93% (95% CI, 90-97%) and a sensitivity of 77% (95% CI, 59-96%). Moreover, the addition of exercise E/e' improved the sensitivity of HFpEF diagnostic algorithms up to 90%, compared with 60 and 34% of guidelines alone. Despite the heterogeneity of the included studies, this review supported the current multivariable-based approach for the diagnosis of HFpEF and LVDD and showed a potential diagnostic role for exercise echocardiography and left atrial strain. Larger well-designed studies are needed to evaluate the incremental value of novel diagnostic tools to current diagnostic algorithms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.