Evidence map›Paper›PMID 32488474›Full record

SynthesisAging clinical and experimental research2021

Association between alcohol intake, mild cognitive impairment and progression to dementia: a dose-response meta-analysis.

Yongfeng Lao, Lijuan Hou, Jing Li, Xu Hui, Peijing Yan, Kehu Yang

Open access · greenAbstract readMeta-AnalysisReview
PubMed Publisher
In one paragraph

Synthesis in Aging clinical and experimental research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 5 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 5 syntheses or guidelines pooled it, 56 citations in OpenAlex.

  1. Pooled it
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  6. Trial
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  12. Activity Engagement Across Stages of Cognitive Health.Healthcare (Basel, Switzerland) · 2025
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  19. Adolescent Alcohol and the Spectrum of Cognitive Dysfunction in Aging.Advances in experimental medicine and biology · 2025
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yongfeng LaoSecond Clinical Medical College, Lanzhou University, Lanzhou, 730000, Gansu, People's Republic of China.
Lijuan HouFirst Clinical Medical College, Lanzhou University, Lanzhou, 730000, Gansu, People's Republic of China.
Jing LiEvidence Based Social Science Research Center, School of Public Health, Lanzhou University, Lanzhou, 730000, Gansu, People's Republic of China.
Xu HuiEvidence Based Social Science Research Center, School of Public Health, Lanzhou University, Lanzhou, 730000, Gansu, People's Republic of China.
Peijing YanEvidence Based Social Science Research Center, School of Public Health, Lanzhou University, Lanzhou, 730000, Gansu, People's Republic of China. calmyan@sina.com.
Kehu YangEvidence Based Social Science Research Center, School of Public Health, Lanzhou University, Lanzhou, 730000, Gansu, People's Republic of China. kehuyangebm2006@126.com.
Lanzhou University · CN

Funding

Fundamental Research Funds for the Central Universities 18LZUJBWZX006, 2019jbkyzy002National Innovation and Entrepreneurship Training Program for Undergraduate 201910730215National Social Science Fund of China 19ZDA142
6 · The paper itself

Abstract

backgroundMild cognitive impairment (MCI) is a cognitive state falling between normal aging and dementia. The relation between alcohol intake and risk of MCI as well as progression to dementia in people with MCI (PDM) remained unclear.

objectiveTo synthesize available evidence and clarify the relation between alcohol intake and risk of MCI as well as PDM.

methodWe searched electronic databases consisting of PubMed, EMBASE, Cochrane Library, and China Biology Medicine disc (CBM) from inception to October 1, 2019. Prospective studies reporting at least three levels of alcohol exposure were included. Categorical meta-analysis was used for quantitative synthesis of the relation between light, moderate and heavy alcohol intake with risk of MCI and PDM. Restricted cubic spline and fixed-effects dose-response models were used for dose-response analysis.

resultSix cohort studies including 4244 individuals were finally included. We observed an unstable linear relation between alcohol intake (drinks/week) and risk of MCI (P linear = 0.0396). It suggested that a one-drink increment per week of alcohol intake was associated with an increased risk of 3.8% for MCI (RR, 1.038; 95% CI 1.002-1.075). Heavy alcohol intake (> 14 drinks/week) was associated with higher risk of PDM (RR = 1.76; 95% CI 1.10-2.82). And we found a nonlinear relation between alcohol intake and risk of PDM. Drinking more than 16 drinks/week (P nonlinear = 0.0038, HR = 1.42; 95% CI 1.00-2.02), or 27.5 g/day (P nonlinear = 0.0047, HR = 1.46; 95% CI 1.00-2.11) would elevate the risk of PDM.

conclusionThere was a nonlinear dose-response relation between alcohol intake and risk of PDM. Excessive alcohol intake would elevate the risk of PDM.

Indexed as

Cognitive DysfunctionDementiaAlcohol DrinkingChinaHumansProspective StudiesAlcoholDementiaDose–responseMeta-analysisMild cognitive impairment

Identifiers

PMID32488474
OpenAlexW3030906074

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.