Evidence map›Paper›PMID 32488375›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2021

Quantitative assessment of cochlear and vestibular ganglion neurons in temporal bones with chronic otitis media.

Rafael da Costa Monsanto, Norma de Oliveira Penido, Mio Uchiyama, Patricia Schachern, Michael M Paparella, Sebahattin Cureoglu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Histopathology of Inner Ear Malformations: Potential Prognostic Factors and Their Influence in the Decision-Making Between CI and ABI.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Rafael da Costa MonsantoDepartment of Otolaryngology Head and Neck Surgery, Universidade Federal de São Paulo/Escola Paulista de Medicina (UNIFESP/EPM), R dos Otonis, 700 - piso superior - Vila Clementino, São Paulo, SP, 04037-004, Brazil. rafaelmonsanto@hotmail.com.ORCID http://orcid.org/0000-0002-9124-593X
Norma de Oliveira PenidoDepartment of Otolaryngology Head and Neck Surgery, Universidade Federal de São Paulo/Escola Paulista de Medicina (UNIFESP/EPM), R dos Otonis, 700 - piso superior - Vila Clementino, São Paulo, SP, 04037-004, Brazil.
Mio UchiyamaDepartment of Otolaryngology, Showa University, Tokyo, Japan.
Patricia SchachernDepartment of Otolaryngology Head and Neck Surgery, University of Minnesota, Minneapolis, MN, USA.
Michael M PaparellaDepartment of Otolaryngology Head and Neck Surgery, University of Minnesota, Minneapolis, MN, USA.
Sebahattin CureogluDepartment of Otolaryngology Head and Neck Surgery, University of Minnesota, Minneapolis, MN, USA.
University of Minnesota · USUniversidade Federal de São Paulo · BRShowa University · JP

Funding

Supplement to Assess the MRI Safety of an Intracranial Auditory Nerve ImplantUG3NS107688 · NINDS · UNIVERSITY OF MINNESOTA · PI ADAMS, MEREDITH EVELYN, FRANKLIN, ROBERT KYLE · 2018 to 2022
$7.0M
Pathology and pathogenesis of otitis media syndromic ear and Meniere's diseaseU24DC011968 · NIDCD · UNIVERSITY OF MINNESOTA · PI CUREOGLU, SEBAHATTIN · 2011 to 2015
$2.2M
NIDCD NIH HHS U24 DC011968NINDS NIH HHS UG3 NS107688NINDS NIH HHS UG3NS107688
6 · The paper itself

Abstract

purposeIn this study, we aimed to determine whether or not COM leads to loss of spiral and Scarpa ganglion neurons.

methodsFrom the human temporal bone (HTB) collection at the University of Minnesota we selected human temporal bones with COM, defined as the presence of clinically intractable tissue abnormalities in the middle ear (cholesteatoma, perforation of the eardrum, granulation tissue, fibrosis, tympanosclerosis, and cholesterol granuloma). We also selected HTBs from donors with no ear diseases as controls. We quantitatively analyzed the number of spiral and Scarpa ganglion cells and compared the results obtained in the control and study groups.

resultsIn both COM and control groups we observed a significant negative correlation between age and number of both spiral (R = -0.632; P < 0.001; 95% CI - 0.766 to - 0.434) and Scarpa ganglion (R = - 0.404; P = 0.008; 95% CI - 0.636 to - 0.051) cells. We did not find any significant differences in the number of spiral ganglion cells (in total or per segment) or in the density of Scarpa ganglion cells (in each vestibular nerve or both) in the COM group as compared with controls (P > 0.05). CONCLUSIONS AND RELEVANCE: Our results did not demonstrate significant loss of cochlear or vestibular peripheral ganglion neuron loss in HTBs with COM as compared with controls.

Indexed as

Otitis MediaVestibular NerveCochleaHumansNeuronsSpiral GanglionTemporal BoneChronic otitis mediaHearing lossOtitis mediaScarpa ganglion cellsSpiral ganglion cellsTinnitusVestibular diseases

Identifiers

PMID32488375
PMCPMC10123924
OpenAlexW3032853291

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.