Evidence map›Paper›PMID 32488373›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2020

Total thyroidectomy with therapeutic level II-IV neck dissection for papillary thyroid carcinoma: level VI recurrence patterns.

Narin N Carmel-Neiderman, Irit Duek, Dana Amsterdam, Anat Wengier, Boris Kuzmenko, Barak Ringel, Anton Warshavsky, Udi Shapira, Gilad Horowitz, Elena Izkhakov and 1 more

Erratum issuedAbstract read
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In one paragraph

Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Construction of prediction models for determining the risk of lateral lymph node metastasis in patients with thyroid papillary carcinoma based on gender stratification.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023
    Article
  3. Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Narin N Carmel-NeidermanDepartment of Otolaryngology, Head and Neck and Maxillofacial Surgery, The Interdisciplinary Center for Head and Neck Surgical Oncology, Tel-Aviv Sourasky Medical Center, 6 Weitzman Street, 6423906, Tel-Aviv, Israel.ORCID http://orcid.org/0000-0003-0628-1942
Irit DuekDepartment of Otolaryngology, Head and Neck and Maxillofacial Surgery, The Interdisciplinary Center for Head and Neck Surgical Oncology, Tel-Aviv Sourasky Medical Center, 6 Weitzman Street, 6423906, Tel-Aviv, Israel.
Dana AmsterdamDepartment of Otolaryngology, Head and Neck and Maxillofacial Surgery, The Interdisciplinary Center for Head and Neck Surgical Oncology, Tel-Aviv Sourasky Medical Center, 6 Weitzman Street, 6423906, Tel-Aviv, Israel.
Anat WengierDepartment of Otolaryngology, Head and Neck and Maxillofacial Surgery, The Interdisciplinary Center for Head and Neck Surgical Oncology, Tel-Aviv Sourasky Medical Center, 6 Weitzman Street, 6423906, Tel-Aviv, Israel.
Boris KuzmenkoDepartment of Otolaryngology, Head and Neck and Maxillofacial Surgery, The Interdisciplinary Center for Head and Neck Surgical Oncology, Tel-Aviv Sourasky Medical Center, 6 Weitzman Street, 6423906, Tel-Aviv, Israel.
Barak RingelDepartment of Otolaryngology, Head and Neck and Maxillofacial Surgery, The Interdisciplinary Center for Head and Neck Surgical Oncology, Tel-Aviv Sourasky Medical Center, 6 Weitzman Street, 6423906, Tel-Aviv, Israel.
Anton WarshavskyDepartment of Otolaryngology, Head and Neck and Maxillofacial Surgery, The Interdisciplinary Center for Head and Neck Surgical Oncology, Tel-Aviv Sourasky Medical Center, 6 Weitzman Street, 6423906, Tel-Aviv, Israel.
Udi ShapiraDepartment of Otolaryngology, Head and Neck and Maxillofacial Surgery, The Interdisciplinary Center for Head and Neck Surgical Oncology, Tel-Aviv Sourasky Medical Center, 6 Weitzman Street, 6423906, Tel-Aviv, Israel.
Gilad HorowitzDepartment of Otolaryngology, Head and Neck and Maxillofacial Surgery, The Interdisciplinary Center for Head and Neck Surgical Oncology, Tel-Aviv Sourasky Medical Center, 6 Weitzman Street, 6423906, Tel-Aviv, Israel.
Elena IzkhakovEndocrinology Unit, Tel Aviv Sourasky Medical Center, affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Dan M FlissDepartment of Otolaryngology, Head and Neck and Maxillofacial Surgery, The Interdisciplinary Center for Head and Neck Surgical Oncology, Tel-Aviv Sourasky Medical Center, 6 Weitzman Street, 6423906, Tel-Aviv, Israel. danf@tlvmc.gov.il.
Tel Aviv Sourasky Medical Center · ILTel Aviv University · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveLateral and central compartments cervical lymph nodes metastases are common among patients with papillary thyroid carcinoma (PTC). Elective level VI neck dissection during thyroidectomy and lateral neck dissection (LND) for the treatment of PTC with lateral compartment lymph node metastases is controversial because of the uncertain benefit in clinical outcomes and increased risks of surgical morbidity. We aimed to determine the potential benefit of elective level VI neck dissection in patients with cN1 papillary thyroid carcinoma (PTC) by investigating the rate and pattern of locoregional recurrence in PTC patients who underwent total thyroidectomy and therapeutic lateral node dissection (LND; levels II-IV) without elective level VI dissection.

methodsA retrospective cohort study. Data on demographics, clinical presentation and workup, intraoperative and pathological report, postoperative course, adjuvant therapy, recurrence patterns, and overall survival were retrieved from the medical charts of patients who underwent thyroid surgery in our hospital between January 2006 and December 2017.

resultsA total of 1415 thyroidectomies were performed during the study period, of which 802 (56.67%) were for PTC. Of those PTC patients, 228 (28.42%) also underwent LND (levels II-VI) during the same thyroidectomy procedure. Thirty-four (14.91%) of those 228 patients, underwent total thyroidectomy with therapeutic lateral ND II-IV without elective level VI ND. During the follow-up period, five (14.7%) of the latter cohort were diagnosed with recurrence in central neck (level VI) lymph nodes, and four of them (11.7%) were diagnosed with ipsilateral recurrence at level VI.

conclusionOur results revealed 11.7% rate of clinically significant recurrent disease in ipsilateral level VI which, in our opinion, does not justify routine prophylactic level VI ND dissection when the ipsilateral lateral neck is operated for metastases.

Indexed as

Carcinoma, PapillaryThyroid NeoplasmsHumansLymph NodesNeck DissectionNeoplasm Recurrence, LocalRetrospective StudiesThyroid Cancer, PapillaryThyroidectomyCentral compartmentLymph node metastasesNeck dissectionPapillary thyroid carcinomaThyroid

Identifiers

PMID32488373
OpenAlexW3031088872

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.