ArticleScientific reports2020
Repetitive, mild traumatic brain injury results in a progressive white matter pathology, cognitive deterioration, and a transient gut microbiota dysbiosis.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.
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Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Temporal patterns of microglial activation in white matter following experimental mild traumatic brain injury: a systematic literature review.Acta neuropathologica communications · 2021Pooled it
- Mouse closed head traumatic brain injury replicates the histological tau pathology pattern of human disease: characterization of a novel model and systematic review of the literature.Acta neuropathologica communications · 2021Pooled it
- Mild and repetitive mild traumatic brain injury: Changes in microglial cells and synapses.Neural regeneration research · 2026Article
- Non-invasive Vagal Nerve Stimulation as a Potential Treatment for Repetitive Blast Trauma.bioRxiv : the preprint server for biology · 2026Article
- Mild concussion impairs extinction of avoidance and alters respective brain circuits in male rats.Experimental neurology · 2026Article
- Spatial associations between neuronal membrane damage and vasculature after repetitive diffuse TBI in pigs.Acta neuropathologica communications · 2026Article
- A curcumin-resveratrol-carnosic acid complex mitigates brain-gut axis disruption in a rodent model of repeated mild traumatic brain injury.Metabolic brain disease · 2026Article
- Quercetin hybrid-hydrogel microparticles modulate gut microbiota and improve memory in an antibiotic-induced dysbiosis rat model.Scientific reports · 2025Article
- The Gut Microbiome as a Modulator of Traumatic Brain Injury Pathology and Symptoms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Systematic review and meta-analysis of microbiota-gut-astrocyte axis perturbation in neurodegeneration, brain injury, and mood disorders.Brain, behavior, & immunity - health · 2025Review
- Association between traumatic brain injury and risk of developing infections in the central nervous system and periphery.Metabolic brain disease · 2025Review
- The Gut Microbiome Regulates the Psychomotor Effects and Context-Dependent Rewarding Responses to Cocaine in Germ-Free and Antibiotic-Treated Animal Models.Microorganisms · 2025Article
- Investigating the Impact of Turmeric on Neuroinflammation and Degenerative Changes in Repetitive Traumatic Brain Injuries: Insights from Murine Model.Korean journal of neurotrauma · 2025Article
- Nomogram establishment for gastrointestinal bleeding prediction in ICU patients with traumatic brain injury based on the MIMIC-IV database.Frontiers in medicine · 2025Article
- Gut Microbial Composition Is Associated with Symptom Self-Report in Trauma-Exposed Iraq and Afghanistan Veterans.Neurotrauma reports · 2025Article
- Actomyosin-II protects axons from degeneration induced by mild mechanical stress.The Journal of cell biology · 2024Article
- Antibiotic treatment induces microbiome dysbiosis and reduction of neuroinflammation following traumatic brain injury in mice.Research square · 2024Article
- Acute gastrointestinal permeability after traumatic brain injury in mice precedes a bloom in Akkermansia muciniphila supported by intestinal hypoxia.Scientific reports · 2024Article
- Long access heroin self-administration significantly alters gut microbiome composition and structure.Frontiers in psychiatry · 2024Article
- Research progress on the relationship between traumatic brain injury and brain-gut-microbial axis.Ibrain · 2024Review
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Traumatic brain injury (TBI) is often accompanied by gastrointestinal and metabolic disruptions. These systemic manifestations suggest possible involvement of the gut microbiota in head injury outcomes. Although gut dysbiosis after single, severe TBI has been documented, the majority of head injuries are mild, such as those that occur in athletes and military personnel exposed to repetitive head impacts. Therefore, it is important to determine if repetitive, mild TBI (rmTBI) will also disrupt the gut microbiota. Male mice were exposed to mild head impacts daily for 20 days and assessed for cognitive behavior, neuropathology and disruptions in the gut microbiota at 0, 45 or 90 days after injury. Deficits in recognition memory were evident at the late post-injury points. Brains show an early increase in microglial activation at the 0-day time point that persisted until 90 days post-injury. This was compounded by substantial increases in astrocyte reactivity and phosphorylated tau at the 90-day time point. In contrast, changes in the microbial community were minor and transient, and very few differences were observed in mice exposed to rmTBI compared to controls. While the progressive emergence of white matter damage and cognitive alterations after rmTBI resembles the alterations observed in athletes and military personnel exposed to rmTBI, these changes could not be linked to systematic modifications in the gut microbiota.
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