ArticleScientific reports2020
Reproductive effects of subchronic exposure to acetamiprid in male rats.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
32 citing papers in PubMed, 73 citations in OpenAlex.
- Chrysin Mitigates Acetamiprid-Induced Testicular Injury in Mice via Suppression of Endoplasmic Reticulum Stress and Inflammation.Environmental toxicology · 2026Article
- Ameliorative Effects of Berberine Against Acetamiprid-Induced Toxicity in the Testes of Rats: A Computational and Histological Insight.Journal of xenobiotics · 2026Article
- Sex and adrenal hormone alteration in Ecuadorian adolescents with home and school proximity to floriculture crop area.Environmental health : a global access science source · 2026Article
- Intermittent Fasting Ameliorates Testicular Damage via Oxidative Stress Modulation in a Genetic Absence Epilepsy Rat Model.International journal of molecular sciences · 2026Article
- Dietary exposure to pesticides in poultry: From semen quality to embryonic mortality and tissue accumulation.Poultry science · 2026Article
- Neonicotinoids and the Androgen Receptor: Structural Dynamics and Potential Signaling Disruption.Biology · 2026Article
- Protective effect ofFrontiers in veterinary science · 2026Article
- Simultaneous semen and urine biomonitoring of neonicotinoids and associations with semen quality in men.Frontiers in endocrinology · 2026Article
- The distribution of neonicotinoids and their metabolites in paired semen and urine samples and associations with male reproductive hormones.Frontiers in endocrinology · 2026Article
- Ecological and reproductive consequences of endocrine-disrupting chemicals in agricultural systems.Reproduction & fertility · 2026Review
- Alpha-Tocopherol Protects Porcine Oocytes from Acetamiprid-Induced Meiotic Defects by Alleviating Oxidative Stress-Mediated Ferroptosis.Antioxidants (Basel, Switzerland) · 2025Article
- Medical Ozone Treatment Attenuates Male Reproductive Toxicity Induced by Bleomycin, Etoposide, and Cisplatin Regimen in an Experimental Animal Model.International journal of molecular sciences · 2025Article
- Insecticides and testicular health: mechanisms of injury and protective natural products.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Co-treatment of β-carotene with acetamiprid provides protection against acetamiprid induced hepatic and renal toxicity via modulation of the antioxidant system.BMC pharmacology & toxicology · 2025Article
- Acetamiprid-induced testicular toxicity in mice: ameliorative effect and potential mechanisms of morin.BMC complementary medicine and therapies · 2025Article
- The impact of neonicotinoid pesticides on reproductive health.Toxicological sciences : an official journal of the Society of Toxicology · 2025Review
- Berberine Attenuates Acetamiprid Exposure-Induced Mitochondrial Dysfunction and Apoptosis in Rats via Regulating the Antioxidant Defense System.Journal of xenobiotics · 2024Article
- Thiacloprid impairs reproductive functions of male Wistar rats.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Cinnamon nanoemulsion mitigates acetamiprid-induced hepatic and renal toxicity in rats: biochemical, histopathological, immunohistochemical, and molecular docking analysis.BMC veterinary research · 2024Article
- Sex and adrenal hormones in association with insecticide biomarkers among adolescents living in ecuadorian agricultural communities.International journal of hygiene and environmental health · 2024Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acetamiprid, a selective agonist of nicotinic acetylcholine recetors, is one of the most widely used neonicotinoids. There is limited data about toxicity of acetamiprid on male reproductive system. Therefore, the study aimed to investigate the reproductive toxic potential of acetamiprid in male rats orally treated with acetamiprid with low (12.5 mg/kg) medium (25 mg/kg) or high dose (35 mg/kg) for 90 days. According to our results, sperm concentration and plasma testosterone levels decreased in dose dependent manner. Gonadotropin-releasing hormone (GnRH), follicle-stimulating hormeone (FSH), luteinizing hormone (LH) levels increased at low and medium dose groups and acetamiprid caused lipid peroxidation and glutathione (GSH) depletion in the testes. Histologic examinations revealed that acetamiprid induced apoptosis in medium and high dose groups and proliferation index dramatically decreased in high dose group. In conclusion, acetamiprid caused toxicity on male reproductive system in the high dose. The mechanism of the toxic effect may be associated with oxidative stress, hormonal disruptions and apoptosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.