Evidence map›Paper›PMID 32488015›Full record

ArticleNature communications2020

Role of serotonergic dorsal raphe neurons in hypercapnia-induced arousals.

Satvinder Kaur, Roberto De Luca, Mudasir A Khanday, Sathyajit S Bandaru, Renner C Thomas, Rebecca Y Broadhurst, Anne Venner, William D Todd, Patrick M Fuller, Elda Arrigoni and 1 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 63 citations in OpenAlex.

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  11. Genetic associations between serotonin receptor 1F (The European respiratory journal · 2025
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  12. Serotonin neurons are necessary for tonic sodium intake inhibition.American journal of physiology. Regulatory, integrative and comparative physiology · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Satvinder KaurDepartment of Neurology, Division of Sleep Medicine, and Program in Neuroscience, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02215, USA.ORCID http://orcid.org/0000-0002-8243-2880
Roberto De LucaDepartment of Neurology, Division of Sleep Medicine, and Program in Neuroscience, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02215, USA.
Mudasir A KhandayDepartment of Neurology, Division of Sleep Medicine, and Program in Neuroscience, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02215, USA.
Sathyajit S BandaruDepartment of Neurology, Division of Sleep Medicine, and Program in Neuroscience, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02215, USA.
Renner C ThomasDepartment of Neurology, Division of Sleep Medicine, and Program in Neuroscience, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02215, USA.
Rebecca Y BroadhurstDepartment of Neurology, Division of Sleep Medicine, and Program in Neuroscience, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02215, USA.
Anne VennerDepartment of Neurology, Division of Sleep Medicine, and Program in Neuroscience, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02215, USA.ORCID http://orcid.org/0000-0001-7481-3248
William D ToddDepartment of Neurology, Division of Sleep Medicine, and Program in Neuroscience, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02215, USA.ORCID http://orcid.org/0000-0002-0919-3043
Patrick M FullerDepartment of Neurology, Division of Sleep Medicine, and Program in Neuroscience, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02215, USA.
Elda ArrigoniDepartment of Neurology, Division of Sleep Medicine, and Program in Neuroscience, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02215, USA.
Clifford B SaperDepartment of Neurology, Division of Sleep Medicine, and Program in Neuroscience, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02215, USA. csaper@bidmc.harvard.edu.ORCID http://orcid.org/0000-0002-5788-3014
Beth Israel Deaconess Medical Center · US

Funding

Wakefulness and Forebrain Activation by Orexin NeuronsP01HL095491 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI WELLMAN, DAVID ANDREW · 2010 to 2019
$25.1M
Project 5: Novel strategies to prevent opioid-induced hypoventilation during sleep and identification of underlying mechanismsP01HL149630 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Roberto De Luca · 2020 to 2026
$22.3M
Molecular-Genetic Dissection of Subcortical Circuitry Regulating ArousalR01NS073613 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Patrick M Fuller · 2011 to 2026
$5.5M
Hypothalamic arousal systemsR01NS085477 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SAPER, CLIFFORD B · 2014 to 2018
$2.8M
Dissection of the Circuitry Regulating Arousal to PainR01NS112175 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KAUR, SATVINDER · 2019 to 2023
$1.9M
NHLBI NIH HHS P01 HL095491NHLBI NIH HHS P01 HL149630NINDS NIH HHS R01 NS073613NINDS NIH HHS R01 NS085477NINDS NIH HHS R01 NS112175
6 · The paper itself

Abstract

During obstructive sleep apnea, elevation of CO

Indexed as

AnimalsArousalBrain StemCalcitonin Gene-Related PeptideCarbon DioxideDisease Models, AnimalDorsal Raphe NucleusHypercapniaMaleMiceMice, TransgenicOptogeneticsParabrachial NucleusSerotonergic NeuronsSerotoninSerotonin Plasma Membrane Transport ProteinsCalcitonin Gene-Related PeptideCarbon DioxideSerotoninSerotonin Plasma Membrane Transport ProteinsSlc6a4 protein, mouse

Identifiers

PMID32488015
PMCPMC7265411
OpenAlexW3030404206

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.