ArticleNature communications2020
Low-dose phase retrieval of biological specimens using cryo-electron ptychography.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Electrons and X-rays for diffraction and imaging.Acta crystallographica. Section D, Structural biology · 2026Review
- Damage-limited resolution for X-ray and electron microscopy of organic specimens.Acta crystallographica. Section D, Structural biology · 2026Article
- Electron fourier ptychography for phase reconstruction.Scientific reports · 2025Article
- Sub-ångström resolution ptychography in a scanning electron microscope at 20 keV.Nature communications · 2025Article
- Dose-efficient cryo-electron microscopy for thick samples using tilt- corrected scanning transmission electron microscopy.Nature methods · 2025Article
- Roadmap for Quantum Nanophotonics with Free Electrons.ACS photonics · 2025Review
- Ptychoscopy: a user friendly experimental design tool for ptychography.Scientific reports · 2025Article
- Phase Imaging Methods in the Scanning Transmission Electron Microscope.Nano letters · 2025Review
- Serial coherent diffraction imaging of dynamic samples based on inter-frame continuity.Light, science & applications · 2025Article
- Atomically resolved imaging of radiation-sensitive metal-organic frameworks via electron ptychography.Nature communications · 2025Article
- Simulation Study of Low-Dose 4D-STEM Phase Contrast Techniques at the Nanoscale in SEM.Nanomaterials (Basel, Switzerland) · 2025Article
- In-situ microscopy and digital image correlation to study the mechanical characteristics of polymer-based materials.Discover materials · 2025Review
- Review
- Cryo-electron microscopy in color.Nature methods · 2024Article
- Ptychographic phase retrieval via a deep-learning-assisted iterative algorithm.Journal of applied crystallography · 2024Article
- Low-dose cryo-electron ptychography of proteins at sub-nanometer resolution.Nature communications · 2024Article
- Article
- An efficient ptychography reconstruction strategy through fine-tuning of large pre-trained deep learning model.iScience · 2023Article
- Solving complex nanostructures with ptychographic atomic electron tomography.Nature communications · 2023Article
- Article
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Authors and funding
17 authors.
Funding
Abstract
Cryo-electron microscopy is an essential tool for high-resolution structural studies of biological systems. This method relies on the use of phase contrast imaging at high defocus to improve information transfer at low spatial frequencies at the expense of higher spatial frequencies. Here we demonstrate that electron ptychography can recover the phase of the specimen with continuous information transfer across a wide range of the spatial frequency spectrum, with improved transfer at lower spatial frequencies, and as such is more efficient for phase recovery than conventional phase contrast imaging. We further show that the method can be used to study frozen-hydrated specimens of rotavirus double-layered particles and HIV-1 virus-like particles under low-dose conditions (5.7 e/Å
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