ArticleNature communications2020
A hypomorphic cystathionine ß-synthase gene contributes to cavefish eye loss by disrupting optic vasculature.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.
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22 citing papers in PubMed, 37 citations in OpenAlex.
- Exploring Astyanax mexicanus as a model for unraveling genotype-environment interactions and metabolic adaptations.Lab animal · 2026Review
- Automated Profiling of Social Behaviors to Assess the Genetic Basis of Evolution of Aggressive Behaviors in Astyanax mexicanus.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2026Article
- Convergent evolution of albinism in cave animals is driven by shared mechanisms and adaptive advantages.Communications biology · 2026Article
- Novel mechanisms of chemosensory adaptation to the cave environment.bioRxiv : the preprint server for biology · 2026Article
- CRISPR screening reveals genetic regulators associated with the evolution of eye degeneration.bioRxiv : the preprint server for biology · 2025Article
- From Genomic Fossils to Functional Elements: The Evolving Story of Pseudogenes.Advanced genetics (Hoboken, N.J.) · 2025Review
- The rx3 Gene Contributes to the Evolution of Eye Loss in the Cavefish Astyanax mexicanus.Evolution & development · 2025Article
- Comparative Embryology and Transcriptomics of Asellus infernus, an Isopod Crustacean From Sulfidic Groundwater.Evolution & development · 2025Article
- Hypoxia-sonic hedgehog axis as a driver of primitive hematopoiesis development and evolution in cavefish.Developmental biology · 2024Article
- The spatiotemporal and genetic architecture of extraoral taste buds in Astyanax cavefish.Communications biology · 2024Article
- Wall-following - Phylogenetic context of an enhanced behaviour in stygomorphicEcology and evolution · 2024Article
- The nature and distribution of putative non-functional alleles suggest only two independent events at the origins of Astyanax mexicanus cavefish populations.BMC ecology and evolution · 2024Article
- From darkness to discovery: evolutionary, adaptive, and translational genetic insights from cavefish.Trends in genetics : TIG · 2024Review
- Trait Loss in Evolution: What Cavefish Have Taught Us about Mechanisms Underlying Eye Regression.Integrative and comparative biology · 2023Review
- Discovery of putative long non-coding RNAs expressed in the eyes of Astyanax mexicanus (Actinopterygii: Characidae).Scientific reports · 2023Article
- ZooKeys · 2023Article
- Natural selection versus neutral mutation in the evolution of subterranean life: A false dichotomy?Frontiers in ecology and evolution · 2023Article
- Novel genome sequence of Chinese cavefish (Triplophysa rosa) reveals pervasive relaxation of natural selection in cavefish genomes.Molecular ecology · 2022Article
- Article
- Genetic mapping of metabolic traits in the blind Mexican cavefish reveals sex-dependent quantitative trait loci associated with cave adaptation.BMC ecology and evolution · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Vestigial structures are key indicators of evolutionary descent, but the mechanisms underlying their development are poorly understood. This study examines vestigial eye formation in the teleost Astyanax mexicanus, which consists of a sighted surface-dwelling morph and multiple populations of blind cave morphs. Cavefish embryos initially develop eyes, but they subsequently degenerate and become vestigial structures embedded in the head. The mutated genes involved in cavefish vestigial eye formation have not been characterized. Here we identify cystathionine ß-synthase a (cbsa), which encodes the key enzyme of the transsulfuration pathway, as one of the mutated genes responsible for eye degeneration in multiple cavefish populations. The inactivation of cbsa affects eye development by increasing the transsulfuration intermediate homocysteine and inducing defects in optic vasculature, which result in aneurysms and eye hemorrhages. Our findings suggest that localized modifications in the circulatory system may have contributed to the evolution of vestigial eyes in cavefish.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.