Evidence map›Paper›PMID 32487816›Full record

ReviewCurrent opinion in HIV and AIDS2020

Identifying and managing infectious disease syndemics in patients with HIV.

Daniel J Bromberg, Kenneth H Mayer, Frederick L Altice

Registry-linked trialOpen access · greenAbstract readReview
In one paragraph

Review in Current opinion in HIV and AIDS, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07560046 (Combating Related Epidemics in HCV Through Simplified Testing and Treatment. A Cluster Randomized Trial of Point-of-care Hepatitis C Testing and Treatment Among Key Populations), which is not on this map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
0.4field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07560046 phase4not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Combating Related Epidemics in HCV Through Simplified Testing and Treatment. A Cluster Randomized Trial of Point-of-care Hepatitis C Testing and Treatment Among Key Populations

TypeinterventionalSponsorDuke UniversityRan2026 to 2030Enrolled1,280ConditionsHIV - Human Immunodeficiency Virus, Hepatitis B Virus (HBV), HEPATITIS C (HCV)ArmsCepheid GeneXpert HCV Test, Abbott Determine HIV - 1/2 Ag/Ab, Abbott Determine HbsAg 2, Sofosbuvir / Velpatasvir Oral Tablet [Epclusa]
3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 38 citations in OpenAlex.

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  11. Psychosocial Phenotype and Risky Sexual Behavior Among People Living with HIV in Changsha: A Latent Profile Analysis.International journal of sexual health : official journal of the World Association for Sexual Health · 2025
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Daniel J BrombergDepartment of Social and Behavioral Sciences, Yale University School of Public Health.
Kenneth H MayerThe Fenway Institute, Fenway Health.
Frederick L AlticeYale Center for Interdisciplinary Research on AIDS, Yale University, New Haven, Connecticut.
Yale University · USBeth Israel Deaconess Medical Center · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI RAJESH T GANDHI · 2004 to 2026
$94.4M
INTERDISCIPLINARY HIV PREVENTION TRAINING PROGRAMT32MH020031 · NIMH · YALE UNIVERSITY · PI Trace S Kershaw · 1999 to 2026
$12.1M
Prison Interventions and HIV Prevention CollaborationR01DA029910 · NIDA · YALE UNIVERSITY · PI FREDERICK LEWIS ALTICE · 2010 to 2026
$7.9M
Expanding Medication Assisted Therapy in Ukraine (ExMAT)R01DA033679 · NIDA · YALE UNIVERSITY · PI ALTICE, FREDERICK LEWIS · 2012 to 2021
$6.4M
Integrating Addiction Treatment and HIV Services into Primary Care Clinics in UkraineR01DA043125 · NIDA · YALE UNIVERSITY · PI ALTICE, FREDERICK LEWIS · 2016 to 2021
$4.4M
Naltrexone for Opioid Dependent Released HIV+ Criminal Justice PopulationsR01DA030762 · NIDA · YALE UNIVERSITY · PI SPRINGER, SANDRA ANN · 2010 to 2015
$4.1M
HIV, Buprenorphine, and the Criminal Justice SystemR01DA030768 · NIDA · YALE UNIVERSITY · PI ALTICE, FREDERICK LEWIS · 2010 to 2015
$4.0M
Addiction, HIV and Tuberculosis in Malaysian Criminal Justice SettingsR01DA041271 · NIDA · YALE UNIVERSITY · PI SHENOI, SHEELA · 2016 to 2021
$3.3M
Direct/Observed Therapy/Community-Released HIV+PrisonersR01DA017059 · NIDA · YALE UNIVERSITY · PI ALTICE, FREDERICK LEWIS · 2004 to 2008
$3.3M
Intervention of HIV, Drug Use and the Criminal Justice System in MalaysiaR01DA025943 · NIDA · YALE UNIVERSITY · PI ALTICE, FREDERICK LEWIS · 2008 to 2012
$2.7M
Enhancing Health Outcomes Among HIV+ Substance AbusersK24DA017072 · NIDA · YALE UNIVERSITY · PI ALTICE, FREDERICK LEWIS · 2003 to 2012
$1.5M
NCATS NIH HHS UL1 TR001863NIAID NIH HHS P30 AI060354NIDA NIH HHS K24 DA017072NIDA NIH HHS R01 DA017059NIDA NIH HHS R01 DA025943NIDA NIH HHS R01 DA029910NIDA NIH HHS R01 DA030762NIDA NIH HHS R01 DA030768NIDA NIH HHS R01 DA033679NIDA NIH HHS R01 DA041271NIDA NIH HHS R01 DA043125NIDA NIH HHS R21 DA019843NIDA NIH HHS R21 DA039842NIDA NIH HHS R21 DA041953NIMH NIH HHS T32 MH020031
6 · The paper itself

Abstract

purpose of reviewWe will present recent articles focusing on HIV synergistic interactions with other sexually transmitted infections, tuberculosis, and hepatitis, as well as recent advances in the study of social and behavioral determinants that facilitate this clustering of infectious disease. For each synergistic interaction, we highlight evidence-based interventions that clinicians and policymakers should consider to tackle HIV and infectious disease syndemics. RECENT

findingsSignificant advances in understanding the behavioral and structural determinants of HIV and other infectious disease synergisms have been made in the past years. Intervention strategies based on these new models have also been developed. It is now well understood that treating infectious disease syndemics will require a multidisciplinary and multipronged approach. SUMMARY: HIV is synergistic with multiple other infectious diseases because the risk behaviors that lead to HIV acquisition may be similar to the other infections. The influence of HIV on the other infection may be due to immunosuppression associated with disease progression resulting in increased susceptibility (e.g., HIV and tuberculosis), especially when patients are not virologically suppressed using antiretroviral therapy. In reverse, another infectious disease may, when not treated, influence HIV disease progression. Social/structural determinants like homelessness, mass incarceration, and structural discrimination precipitate psychiatric comorbidity, substance use, and risky sex behavior which lead to the spread and co-occurrence of infectious disease.

Indexed as

HIV InfectionsSexually Transmitted DiseasesTuberculosisHumansSexual BehaviorSyndemic

Identifiers

PMID32487816
PMCPMC7376494
OpenAlexW3031665721

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.