Evidence map›Paper›PMID 32487771›Full record

Observational studyOpen heart2020

Preoperative disturbances of glucose metabolism and mortality after coronary artery bypass grafting.

Catarina Djupsjo, Ulrik Sartipy, Torbjorn Ivert, Stelios Karayiannides, Pia Lundman, Thomas Nystrom, Martin J Holzmann, Jeanette Kuhl

Abstract readObservational Study
In one paragraph

Observational study in Open heart, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Catarina DjupsjoMedicine, Karolinska Institute, Stockholm, Stockholm County, Sweden.ORCID 0000-0002-8250-0097
Ulrik SartipyMolecular Medicine and Surgery, Karolinska Institute, Stockholm, Stockholm County, Sweden.ORCID 0000-0003-2707-0263
Torbjorn IvertMolecular Medicine and Surgery, Karolinska Institute, Stockholm, Stockholm County, Sweden.
Stelios KarayiannidesClinical Sciences, Karolinska Institute, Stockholm, Stockholm County, Sweden.
Pia LundmanClinical Sciences, Karolinska Institute, Stockholm, Stockholm County, Sweden.
Thomas NystromClinical Science and Research, Karolinska Institute, Stockholm, Stockholm County, Sweden.
Martin J HolzmannMedicine, Karolinska Institute, Stockholm, Stockholm County, Sweden.
Jeanette KuhlMedicine, Karolinska Institute, Stockholm, Stockholm County, Sweden Jeanette.kuhl@ki.se.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDisturbances of glucose metabolism are important risk factors for coronary artery disease and are associated with an increased mortality risk. The aim was to investigate the association between preoperative disturbances of glucose metabolism and long-term all-cause mortality after coronary artery bypass grafting (CABG).

methodsPatients undergoing a first isolated CABG in 2005-2013 were included. All patients without previously known diabetes underwent an oral glucose tolerance test (OGTT) before surgery. They were categorised as having normal glucose tolerance (NGT), pre-diabetes (impaired glucose tolerance and/or impaired fasting glucose) or newly discovered diabetes. Data were collected from nationwide healthcare registers. Cox regression was used to calculate adjusted HR with 95% CI for death in patients with pre-diabetes and diabetes, using NGT as reference.

resultsIn total, 497 patients aged 40-86 years were included. According to OGTT, 170 (34%) patients had NGT, 219 (44%) patients with pre-diabetes and 108 (22%) patients had newly discovered diabetes. Baseline characteristics were similar between the groups except for slightly higher age among patients with newly discovered diabetes. There were 133 (27%) deaths during a mean follow-up time of 10 years. The cumulative 10-year survival was 77% (69%-83%), 83% (77%-87%) and 71% (61%-79%) in patients with NGT, pre-diabetes and newly discovered diabetes, respectively. There was no significant difference in all-cause mortality between the groups after multivariable adjustment.

conclusionIn this study, patients with pre-diabetes or newly discovered diabetes prior to CABG had similar long-term survival compared with patients with NGT.

Indexed as

AdultAgedAged, 80 and overBiomarkersBlood GlucoseCoronary Artery BypassCoronary Artery DiseaseDiabetes MellitusFemaleHumansMaleMiddle AgedPrediabetic StateRegistriesRisk AssessmentRisk FactorsBiomarkersBlood Glucoseacute coronary syndromecoronary artery diseasediabetic heart diseasesurgery-coronary bypass

Identifiers

PMID32487771
PMCPMC7269542

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.