Evidence map›Paper›PMID 32487749›Full record

ArticleThe Journal of biological chemistry2020

Early cleavage of preimplantation embryos is regulated by tRNA

Xiaoxu Chen, Yi Zheng, Anmin Lei, Hanxue Zhang, Huimin Niu, Xueliang Li, Pengfei Zhang, Mingzhi Liao, Yinghua Lv, Zhendong Zhu and 8 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 75 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Small Non-coding RNAs and Male Infertility.Advances in experimental medicine and biology · 2026
    Review
  7. Amyloid-mediated RNA uptake by sperm for embryonic delivery.bioRxiv : the preprint server for biology · 2025
    Article
  8. Phthalate exposure to adult mice alters non-coding RNAs in cauda epididymosomes.Environmental pollution (Barking, Essex : 1987) · 2025
    Article
  9. Role of Seminal Exosomes in Reproduction.Journal of cellular physiology · 2025
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
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  17. Review
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 7 institutions in 4 countries.

Xiaoxu ChenKey Laboratory for Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
Yi ZhengKey Laboratory for Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China y.zheng@nwafu.edu.cn zengsm@cau.edu.cn zengwenxian2015@126.com.
Anmin LeiCollege of Veterinary Medicine, Shaanxi Stem Cell Engineering and Technology Center, Northwest A&F University, Yangling, Shaanxi, China.
Hanxue ZhangLaboratory of Animal Embryonic Biotechnology, National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics, Breeding and Reproduction of the Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University, Beijing, China.
Huimin NiuCollege of Veterinary Medicine, Shaanxi Stem Cell Engineering and Technology Center, Northwest A&F University, Yangling, Shaanxi, China.
Xueliang LiKey Laboratory for Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
Pengfei ZhangKey Laboratory for Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
Mingzhi LiaoCollege of Life Science, Northwest A&F University, Yangling, Shaanxi, China.
Yinghua LvCollege of Chemistry and Pharmacy, Northwest A&F University, Yangling, Shaanxi, China.
Zhendong ZhuKey Laboratory for Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
Chuanying PanKey Laboratory for Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
Wuzi DongKey Laboratory for Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
Hong ChenKey Laboratory for Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
De WuKey Laboratory for Animal Disease Resistance Nutrition of the Ministry of Education of China, Institute of Animal Nutrition, Sichuan Agricultural University, Ya'an Chengdu, China.
Wansheng LiuDepartment of Animal Science, Center for Reproductive Biology and Health, College of Agricultural Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA.ORCID 0000-0003-1788-7093
Geert HamerReproductive Biology Laboratory, Center for Reproductive Medicine, Amsterdam Reproduction & Development Research Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Shenming ZengLaboratory of Animal Embryonic Biotechnology, National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics, Breeding and Reproduction of the Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University, Beijing, China y.zheng@nwafu.edu.cn zengsm@cau.edu.cn zengwenxian2015@126.com.
Wenxian ZengKey Laboratory for Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China y.zheng@nwafu.edu.cn zengsm@cau.edu.cn zengwenxian2015@126.com.ORCID 0000-0002-2912-8943
Northwest A&F University · CNNorth West Agriculture and Forestry University · CNAmsterdam University Medical Centers · NLChina Agricultural University · CNMinistry of Agriculture · IDPennsylvania State University · USSichuan Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

tRNA-derived small RNAs (tsRNAs) from spermatozoa could act as acquired epigenetic factors and contribute to offspring phenotypes. However, the roles of specific tsRNAs in early embryo development remain to be elucidated. Here, using pigs as a research model, we probed the tsRNA dynamics during spermatogenesis and sperm maturation and demonstrated the delivery of tsRNAs from semen-derived exosomes to spermatozoa. By microinjection of antisense sequences into

Indexed as

BlastocystCell DivisionAnimalsEmbryonic DevelopmentFemaleMaleMicroinjectionsPregnancyRNARNA, Transfer, GlnSpermatogenesisSpermatozoaSperm MaturationSwineRNARNA, Transfer, Glndevelopmentembryoembryo cleavageembryo developmentepigeneticsexosomefertilitypreimplantationRNAspermspermatogenesissperm maturationtRNA-derived small RNAs (tsRNAs)tRNAGln-TTG

Identifiers

PMID32487749
PMCPMC7415976
OpenAlexW3032853492

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.