ArticlemSystems2020
Increasing the Hindgut Carbohydrate/Protein Ratio by Cecal Infusion of Corn Starch or Casein Hydrolysate Drives Gut Microbiota-Related Bile Acid Metabolism To Stimulate Colonic Barrier Function.
Article in mSystems, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
37 citing papers in PubMed, 53 citations in OpenAlex.
- Effects of Dietary Protein and Starch Digestion Rates on Jejunal and Cecal Microbial Community States and Feed Efficiency in Raccoon Dogs.Animals : an open access journal from MDPI · 2026Article
- Systematic comparison of seven animal protein sources reveals more favorable glucose homeostasis in mice fed duck protein compared with pork protein, associated with gut microbiota and secondary bile acid metabolism.Food chemistry: X · 2026Article
- Recent Advances in Exploring Casein Peptide Regulation of Inflammatory Bowel Disease from an Intestinal Barrier Perspective: Correlations, Mechanisms, Challenges and Solutions.Foods (Basel, Switzerland) · 2026Review
- Multi-omics integration reveals the link between gut microbiota dysbiosis, host metabolic dysregulation, and aortic inflammation in abdominal aortic aneurysm.BMC microbiology · 2026Article
- High-protein diets increase microbiota associated p-cresol production in the colon and reduce gut barrier function in a sex-dependent manner.European journal of nutrition · 2026Article
- Increasing carbohydrates or nitrogenous compounds by cecal infusion leads to an opposite influence on colonic microbiota and host metabolism in a pig model.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Article
- Gut microbiota and bile acid profiles in purebred vs. crossbred sows: links to oxidative stress and inflammation in late gestation.Microbial genomics · 2025Article
- Protein Malnutrition Facilitates Intestinal Colonization with Highly ResistantbioRxiv : the preprint server for biology · 2025Article
- Camel Milk Protein Ameliorates Ulcerative Colitis by Modulating Gut Microbiota and Amino Acid Metabolism.Nutrients · 2025Article
- Exploring the functional diversity and metabolic activities of the human gut microbiome in Thai adults in response to a prebiotic diet.Microbiology spectrum · 2025Article
- Mechanistic study of the effect of a high-salt diet on the intestinal barrier.Scientific reports · 2025Article
- Metformin-associated gut microbiota remodeling correlates with reinvigorated splenic immunity in aged mice: microbiome-immune crosstalk via the gut-spleen axis.Frontiers in immunology · 2025Article
- The molecular interplay between the gut microbiome and circadian rhythms: an integrated review.Frontiers in microbiology · 2025Review
- Astragalus polysaccharides-induced gut microbiota play a predominant role in enhancing of intestinal barrier function of broiler chickens.Journal of animal science and biotechnology · 2024Article
- The Effect of A2 Milk on Gastrointestinal Symptoms in Comparison to A1/A2 Milk: A Single-center, Randomized, Double-blind, Cross-over Study.Journal of cancer prevention · 2024Article
- Multi-omics reveal mechanisms of high enteral starch diet mediated colonic dysbiosis via microbiome-host interactions in young ruminant.Microbiome · 2024Article
- Bile Acid Metabolic Profiles and Their Correlation with Intestinal Epithelial Cell Proliferation and Barrier Integrity in Suckling Piglets.Animals : an open access journal from MDPI · 2024Article
- Microbiota-accessible fiber activates short-chain fatty acid and bile acid metabolism to improve intestinal mucus barrier in broiler chickens.Microbiology spectrum · 2024Article
- The Role of Carbohydrate Intake on the Gut Microbiome: A Weight of Evidence Systematic Review.Microorganisms · 2023Review
- Vitamin K2 supplementation improves impaired glycemic homeostasis and insulin sensitivity for type 2 diabetes through gut microbiome and fecal metabolites.BMC medicine · 2023Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dietary high protein and low carbohydrate levels compromise colonic microbiota and bile acid metabolism, which underlies a detrimental gut environment. However, it remains unclear if the diet-induced changes in colonic health are due to a change in hindgut nutrient availability and what key intermediates link the microbe-epithelium dialogue. To specifically alter the hindgut nutrient substrate availability, here we used a cecally cannulated pig model to infuse corn starch and casein hydrolysate directly into the cecum to generate a stepwise change of carbohydrate/nitrogenous compound (C/N) ratio. Pigs were cecally infused daily with either saline (Control), corn starch (Starch), or casein hydrolysate (Casein) (
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