ArticleProceedings of the National Academy of Sciences of the United States of America2020
A continuous reaction network that produces RNA precursors.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Hydrogen peroxide on Mars and icy moons: Implications for the search for extraterrestrial signatures of prebiotic chemistry.Fundamental research · 2026Review
- Complex and Messy Prebiotic Chemistry: Obstacles and Opportunities for an RNA World.Life (Basel, Switzerland) · 2026Review
- The Origin of Life in the Early Continental Crust: A Comprehensive Model.Life (Basel, Switzerland) · 2025Article
- Solvothermal Polymerization of Diaminomaleonitrile Reveals Optimal Green Solvents for the Production of C=N-Based Polymers.ACS omega · 2024Article
- Article
- A Prebiotic Precursor to Life's Phosphate Transfer System with an ATP Analog and Histidyl Peptide Organocatalysts.Journal of the American Chemical Society · 2024Article
- Favorable Environments for the Formation of Ferrocyanide, a Potentially Critical Reagent for Origins of Life.ACS earth & space chemistry · 2024Article
- Carbonyl Migration in Uronates Affords a Potential Prebiotic Pathway for Pentose Production.JACS Au · 2023Article
- Towards a prebiotic chemoton - nucleotide precursor synthesis driven by the autocatalytic formose reaction.Chemical science · 2023Article
- Formation of Amino Acids and Carboxylic Acids in Weakly Reducing Planetary Atmospheres by Solar Energetic Particles from the Young Sun.Life (Basel, Switzerland) · 2023Article
- A Physicochemical Consideration of Prebiotic Microenvironments for Self-Assembly and Prebiotic Chemistry.Life (Basel, Switzerland) · 2022Review
- Prebiotic synthesis of noncanonical nucleobases under plausible alkaline hydrothermal conditions.Scientific reports · 2022Article
- Automated Exploration of Prebiotic Chemical Reaction Space: Progress and Perspectives.Life (Basel, Switzerland) · 2021Review
- A robotic prebiotic chemist probes long term reactions of complexifying mixtures.Nature communications · 2021Article
- The Semi-Enzymatic Origin of Metabolic Pathways: Inferring a Very Early Stage of the Evolution of Life.Journal of molecular evolution · 2021Article
- Ecological and Biotechnological Aspects of Pigmented Microbes: A Way Forward in Development of Food and Pharmaceutical Grade Pigments.Microorganisms · 2021Review
- Shielding from UV Photodamage: Implications for Surficial Origins of Life Chemistry on the Early Earth.ACS earth & space chemistry · 2021Article
- Radiolysis generates a complex organosynthetic chemical network.Scientific reports · 2021Article
- Prebiotic Reaction Networks in Water.Life (Basel, Switzerland) · 2020Review
- Photoredox chemistry in the synthesis of 2-aminoazoles implicated in prebiotic nucleic acid synthesis.Chemical communications (Cambridge, England) · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Continuous reaction networks, which do not rely on purification or timely additions of reagents, serve as models for chemical evolution and have been demonstrated for compounds thought to have played important roles for the origins of life such as amino acids, hydroxy acids, and sugars. Step-by-step chemical protocols for ribonucleotide synthesis are known, but demonstrating their synthesis in the context of continuous reaction networks remains a major challenge. Herein, compounds proposed to be important for prebiotic RNA synthesis, including glycolaldehyde, cyanamide, 2-aminooxazole, and 2-aminoimidazole, are generated from a continuous reaction network, starting from an aqueous mixture of NaCl, NH
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