Evidence map›Paper›PMID 32487697›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020

PDK1 Regulates the Maintenance of Cell Body and the Development of Dendrites of Purkinje Cells by pS6 and PKCγ.

Rui Liu, Min Xu, Xiao-Yang Zhang, Min-Jie Zhou, Bing-Yao Zhou, Cui Qi, Bo Song, Qi Fan, Wei-Yan You, Jing-Ning Zhu and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 18 citations in OpenAlex.

  1. Targeting the PDK1/c-Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Rui LiuDepartment of Neurobiology, Key Laboratory of Human Functional Genomics of Jiangsu, Nanjing Medical University, Nanjing 211166, Jiangsu, People's Republic of China.ORCID 0000-0002-9641-5280
Min XuDepartment of Neurobiology, Key Laboratory of Human Functional Genomics of Jiangsu, Nanjing Medical University, Nanjing 211166, Jiangsu, People's Republic of China.
Xiao-Yang ZhangKey Laboratory of Pharmaceutical Biotechnology, Department of Physiology, and Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing 210023, People's Republic of China.
Min-Jie ZhouDepartment of Neurobiology, Key Laboratory of Human Functional Genomics of Jiangsu, Nanjing Medical University, Nanjing 211166, Jiangsu, People's Republic of China.
Bing-Yao ZhouDepartment of Neurobiology, Key Laboratory of Human Functional Genomics of Jiangsu, Nanjing Medical University, Nanjing 211166, Jiangsu, People's Republic of China.
Cui QiDepartment of Neurobiology, Key Laboratory of Human Functional Genomics of Jiangsu, Nanjing Medical University, Nanjing 211166, Jiangsu, People's Republic of China.
Bo SongKey Laboratory of Pharmaceutical Biotechnology, Department of Physiology, and Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing 210023, People's Republic of China.
Qi FanDepartment of Neurobiology, Key Laboratory of Human Functional Genomics of Jiangsu, Nanjing Medical University, Nanjing 211166, Jiangsu, People's Republic of China.
Wei-Yan YouDepartment of Neurobiology, Key Laboratory of Human Functional Genomics of Jiangsu, Nanjing Medical University, Nanjing 211166, Jiangsu, People's Republic of China.
Jing-Ning ZhuKey Laboratory of Pharmaceutical Biotechnology, Department of Physiology, and Institute for Brain Sciences, School of Life Sciences, Nanjing University, Nanjing 210023, People's Republic of China.ORCID 0000-0002-3695-9200
Zhong-Zhou YangState Key Laboratory of Pharmaceutical Biotechnology, Department of Cardiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School and MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, Nanjing, 210061, People's Republic of China.
Jun GaoDepartment of Neurobiology, Key Laboratory of Human Functional Genomics of Jiangsu, Nanjing Medical University, Nanjing 211166, Jiangsu, People's Republic of China gaojun@njmu.edu.cn.ORCID 0000-0002-5925-537X
Nanjing Medical University · CNChina Pharmaceutical University · CNJiangsu Shengze Hospital · CNNanjing Drum Tower Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

3-Phosphoinositide-dependent protein kinase-1 (PDK1) plays a critical role in the development of mammalian brain. Here, we investigated the role of PDK1 in Purkinje cells (PCs) by generating the PDK1-conditional knock-out mice (cKO) through crossing

Indexed as

Signal TransductionAction PotentialsAnimalsBehavior, AnimalCell BodyCerebellumDendritesFemaleMaleMiceMice, KnockoutProtein Kinase CPurkinje CellsPyruvate Dehydrogenase Acetyl-Transferring KinaseRibosomal Protein S6TOR Serine-Threonine KinasesmTOR protein, mousePdk1 protein, mouseProtein Kinase Cprotein kinase C gammaPyruvate Dehydrogenase Acetyl-Transferring KinaseRibosomal Protein S6TOR Serine-Threonine Kinasescell bodycerebellumPDK1PKCγpS6Purkinje cells

Identifiers

PMID32487697
PMCPMC7363466
OpenAlexW3029227656

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.