Evidence map›Paper›PMID 32487688›Full record

ArticleLife science alliance2020

Unbiased yeast screens identify cellular pathways affected in Niemann-Pick disease type C.

Alexandria Colaco, María E Fernández-Suárez, Dawn Shepherd, Lihi Gal, Chen Bibi, Silvia Chuartzman, Alan Diot, Karl Morten, Emily Eden, Forbes D Porter and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Understanding and Treating Niemann-Pick Type C Disease: Models Matter.International journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 3 countries.

Alexandria ColacoDepartment of Pharmacology, University of Oxford, Oxford, UK.ORCID 0000-0001-8612-6357
María E Fernández-SuárezDepartment of Pharmacology, University of Oxford, Oxford, UK.ORCID 0000-0003-4277-2079
Dawn ShepherdDepartment of Pharmacology, University of Oxford, Oxford, UK.
Lihi GalDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
Chen BibiDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.ORCID 0000-0001-6240-3831
Silvia ChuartzmanDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
Alan DiotNuffield Department of Obstetrics and Gynecology, University of Oxford, Oxford, UK.ORCID 0000-0001-5079-8274
Karl MortenNuffield Department of Obstetrics and Gynecology, University of Oxford, Oxford, UK.
Emily EdenInstitute of Ophthalmology-Cell Biology, University College London, London, UK.ORCID 0000-0001-9352-5532
Forbes D PorterEunice Kennedy Shriver National Institute of Child Health and Human Development, National Institute of Health, Bethesda, MD, USA.
Joanna PoultonNuffield Department of Obstetrics and Gynecology, University of Oxford, Oxford, UK.
Nick PlattDepartment of Pharmacology, University of Oxford, Oxford, UK.ORCID 0000-0002-1490-5447
Maya SchuldinerDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.ORCID 0000-0001-9947-115X
Frances M PlattDepartment of Pharmacology, University of Oxford, Oxford, UK frances.platt@pharm.ox.ac.uk.ORCID 0000-0001-7614-0403
University of Oxford · GBWeizmann Institute of Science · ILEunice Kennedy Shriver National Institute of Child Health and Human Development · USUniversity College London · GB

Funding

Medical Research Council MR/J010448/1Medical Research Council MR/M010767/1Wellcome Trust 202834/Z/16/Z
6 · The paper itself

Abstract

Niemann-Pick disease type C (NPC) is a rare lysosomal storage disease caused by mutations in either the

Indexed as

BiomarkersDisease SusceptibilitySignal TransductionAnimalsCarrier ProteinsCHO CellsCricetulusCytoskeletonFibroblastsHumansIntracellular MembranesIntracellular Signaling Peptides and ProteinsMitochondriaMutationNiemann-Pick C1 ProteinNiemann-Pick Disease, Type CBiomarkersCarrier ProteinsIntracellular Signaling Peptides and ProteinsNiemann-Pick C1 ProteinNPC1 protein, human

Identifiers

PMID32487688
PMCPMC7283134
OpenAlexW3026703292

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.