ArticleGenetics2020
The Impact of Recessive Deleterious Variation on Signals of Adaptive Introgression in Human Populations.
Article in Genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 45 citations in OpenAlex.
- Recent advances in methods to characterize archaic introgression in modern humans.Genome research · 2026Review
- Signals of Ancestry-Specific Selection in Gentle Africanized Honey Bees.Genome biology and evolution · 2025Article
- Accessible, Realistic Genome Simulation with Selection Using stdpopsim.Molecular biology and evolution · 2025Article
- TheScience (New York, N.Y.) · 2025Article
- Accessible, realistic genome simulation with selection using stdpopsim.bioRxiv : the preprint server for biology · 2025Article
- Mutational load and adaptive variation are shaped by climate and species range dynamics in Vitis arizonica.The New phytologist · 2025Article
- Neanderthal introgressed ancestry reveals human genomic regions enriched with recessive deleterious mutations.bioRxiv : the preprint server for biology · 2025Article
- A history of multiple Denisovan introgression events in modern humans.Nature genetics · 2024Review
- Revisiting Dominance in Population Genetics.Genome biology and evolution · 2024Review
- Leveraging shared ancestral variation to detect local introgression.PLoS genetics · 2024Article
- Pharmacogenetic Variation in Neanderthals and Denisovans and Implications for Human Health and Response to Medications.Genome biology and evolution · 2023Article
- Ghost admixture in eastern gorillas.Nature ecology & evolution · 2023Article
- Integrating sex-bias into studies of archaic introgression on chromosome X.PLoS genetics · 2023Article
- The impact of modern admixture on archaic human ancestry in human populations.bioRxiv : the preprint server for biology · 2023Article
- MaLAdapt Reveals Novel Targets of Adaptive Introgression From Neanderthals and Denisovans in Worldwide Human Populations.Molecular biology and evolution · 2023Article
- Apportioning archaic variants among modern populations.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- We get by with a little help from our friends: shared adaptive variation provides a bridge to novel ecological specialists during adaptive radiation.Proceedings. Biological sciences · 2022Article
- Denisovans and Homo sapiens on the Tibetan Plateau: dispersals and adaptations.Trends in ecology & evolution · 2022Review
- Demographic History and Natural Selection Shape Patterns of Deleterious Mutation Load and Barriers to Introgression across Populus Genome.Molecular biology and evolution · 2022Article
- The genic view of hybridization in the Anthropocene.Evolutionary applications · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Admixture with archaic hominins has altered the landscape of genomic variation in modern human populations. Several gene regions have been identified previously as candidates of adaptive introgression (AI) that facilitated human adaptation to specific environments. However, simulation-based studies have suggested that population genetic processes other than adaptive mutations, such as heterosis from recessive deleterious variants private to populations before admixture, can also lead to patterns in genomic data that resemble AI. The extent to which the presence of deleterious variants affect the false-positive rate and the power of current methods to detect AI has not been fully assessed. Here, we used extensive simulations under parameters relevant for human evolution to show that recessive deleterious mutations can increase the false positive rates of tests for AI compared to models without deleterious variants, especially when the recombination rates are low. We next examined candidates of AI in modern humans identified from previous studies, and show that 24 out of 26 candidate regions remain significant, even when deleterious variants are included in the null model. However, two AI candidate genes,
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.