ArticleCritical care (London, England)2020
Urine cell cycle arrest biomarkers distinguish poorly between transient and persistent AKI in early septic shock: a prospective, multicenter study.
Article in Critical care (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT02812784 (Can Nephrocheck™ Predict the Reversibility of Early, Acute Kidney Injury During Septic Shock?), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Can Nephrocheck™ Predict the Reversibility of Early, Acute Kidney Injury During Septic Shock?
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Implementation of a kidney protection strategy to prevent acute kidney injury after major surgery in high-risk patients identified by biomarkers: a systematic review and individual participant data meta-analysis of randomized controlled trials.Intensive care medicine · 2026Pooled it
- Development and external validation of a prediction model for major adverse kidney events within 30 days in sepsis associated acute kidney injury: a multi-center retrospective clinical study.BMC medical informatics and decision making · 2026Article
- The use of urinary biomarkers as prognostic tools: predicting kidney outcomes in pediatric acute kidney injury.Pediatric nephrology (Berlin, Germany) · 2025Article
- Biological attributes of zinc-dependent endopeptidases in endothelial dysfunction associated with sepsis: a narrative review.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Review
- Explainable Machine Learning Model for Predicting Persistent Sepsis-Associated Acute Kidney Injury: Development and Validation Study.Journal of medical Internet research · 2025Article
- Early Driving Pressure Is Associated with Major Adverse Kidney Events at 30 Days in ARDS Patients with SARS-CoV-2.Journal of clinical medicine · 2025Article
- Persistent severe acute kidney injury is a major modifiable determinant of outcome during critical illness.Intensive care medicine · 2025Article
- The combination of kidney function variables with cell cycle arrest biomarkers identifies distinct subphenotypes of sepsis-associated acute kidney injury: aRenal failure · 2024Article
- Low HDL-C can be a biomarker to predict persistent severe AKI in septic patients? A retrospective cohort study.European journal of medical research · 2023Article
- Urinary cell cycle biomarkers for the prediction of renal non-recovery in patients with septic acute kidney injury: a prospective study.Clinical and experimental nephrology · 2023Observational
- suPAR links a dysregulated immune response to tissue inflammation and sepsis-induced acute kidney injury.JCI insight · 2023Article
- Performance of the renal resistive index and usual clinical indicators in predicting persistent AKI.Renal failure · 2022Article
- Update on prognosis driven classification of pediatric AKI.Frontiers in pediatrics · 2022Review
- Machine learning for early discrimination between transient and persistent acute kidney injury in critically ill patients with sepsis.Scientific reports · 2021Article
- Correction to: Urine cell cycle arrest biomarkers distinguish poorly between transient and persistent AKI in early septic shock: a prospective, multicenter study.Critical care (London, England) · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe urine biomarkers tissue inhibitor of metalloproteinases-2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP7) have been validated for predicting and stratifying AKI. In this study, we analyzed the utility of these biomarkers for distinguishing between transient and persistent AKI in the early phase of septic shock.
methodsWe performed a prospective, multicenter study in 11 French ICUs. Patients presenting septic shock, with the development of AKI within the first 6 h, were included. Urine [TIMP-2]*[IGFBP7] was determined at inclusion (0 h), 6 h, 12 h, and 24 h. AKI was considered transient if it resolved within 3 days. Discriminative power was evaluated by receiver operating characteristic (ROC) curve analysis.
resultsWe included 184 patients, within a median [IQR] time of 1.0 [0.0-3.0] h after norepinephrine (NE) initiation; 100 (54%) patients presented transient and 84 (46%) presented persistent AKI. Median [IQR] baseline urine [TIMP-2]*[IGFBP7] was higher in the persistent AKI group (2.21 [0.81-4.90] (ng/ml)
conclusionsUrine [TIMP-2]*[IGFBP7] measurements in the early phase of septic shock discriminate poorly between transient and persistent AKI and do not improve clinical prediction over that achieved with the usual variables.
trial registrationNCT02812784.
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