ArticleJournal of orthopaedic surgery and research2020
Single-stage treatment of chronic localized tibial osteomyelitis with local debridement and antibiotic-loaded calcium sulfate implantation: a retrospective study of 42 patients.
Article in Journal of orthopaedic surgery and research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Single versus two-stage management of long-bone chronic osteomyelitis in adults: a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2024Pooled it
- Antibiotic-loaded calcium sulfate in clinical treatment of chronic osteomyelitis: a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2022Pooled it
- A retrospective cohort study comparing the effects on inflammatory response and clinical outcomes of vancomycin-PMMA versus vancomycin-sulfate calcium in chronic osteomyelitis.Annals of medicine · 2026Article
- Outcomes and safety of antibiotic-loaded calcium sulfate beads in orthopaedics: A systematic review and meta-analysis.Journal of orthopaedics · 2026Review
- Local Antibiotic-Loadable Carriers for the Treatment of Chronic Osteomyelitis: A Narrative Review.Bioengineering (Basel, Switzerland) · 2026Review
- Review
- New Alternative Surgical Technique for Managing Proximal Tibia Chronic Osteomyelitis: Anterior Approach with Establishment of Bone Marrow Communication via Intramedullary Reaming.Journal of clinical medicine · 2025Article
- Chronic osteomyelitis after cephalomedullary nailing for intertrochanteric fractures of the femur: carbon fiber rod bone cement combined with calcium sulfate loaded with antibiotics.Journal of orthopaedic surgery and research · 2025Article
- Spontaneous Clavicular Osteomyelitis Caused by Cutibacterium acnes Treated with Calcium Sulfate Beads.Journal of orthopaedic case reports · 2025Article
- Article
- Article
- Exploring versatile applications of a vacuum-assisted bone harvester in orthopedic surgery.BMC musculoskeletal disorders · 2024Article
- Article
- Prevention and treatment of osteomyelitis after open tibia fractures.OTA international : the open access journal of orthopaedic trauma · 2024Review
- The sucker-like end-to-side arterial anastomosis for free flap in extremities reconstruction: a retrospective study of 78 cases.Journal of orthopaedic surgery and research · 2024Article
- Analysis of risk factors for the recurrence of osteomyelitis of the limb after treatment with antibiotic-loaded calcium sulfate and autologous bone graft.Frontiers in bioengineering and biotechnology · 2024Article
- Efficacy and Safety of Antibiotic Impregnated Microporous Nanohydroxyapatite Beads for Chronic Osteomyelitis Treatment: A Multicenter, Open-Label, Prospective Cohort Study.Antibiotics (Basel, Switzerland) · 2023Article
- Does the Use of Local Antibiotics Affect Clinical Outcome of Patients with Fracture-Related Infection?Antibiotics (Basel, Switzerland) · 2022Article
- The Use of Calcium Sulphate Beads in the Management of Osteomyelitis of Femur and Tibia: A Systematic Review.The archives of bone and joint surgery · 2022Review
- Management of chronic osteomyelitis of the femur and tibia: a scoping review.EFORT open reviews · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough various methods have been introduced, the management of chronic tibial osteomyelitis remains a challenge. This study aims to assess a combined treatment method, local debridement combined with antibiotic-loaded calcium sulfate implantation, for the management of the local (Cierny-Mader type III) tibial osteomyelitis.
methodsForty-two patients (43 limbs) with type III tibial osteomyelitis, from January 2012 to December 2018, who received the treatment method mentioned above were included in the study. The infection remission rate, recurrence rate, complications rate, and bone healing rate were respectively analyzed.
resultsWith a mean follow-up of 42.8 months, 38 limbs (37 patients) (88.4%, 38/43) achieved infection remission without recurrence. Among those patients pain, limitation of movement, sinus tracts, topical redness, and swelling were generally eliminated. Only 4 patients felt slight pain after a long-distance walk, while another 6 patients showed minor but acceptable discomfort in affected limbs. Five patients (11.6%) suffered from osteomyelitis recurrence that required secondary surgical and medical treatment, but no amputation was necessary to eliminate the infection. Prolonged aseptic drainage was the most frequent complication that was observed in 13 patients (30.0%). They were successfully managed by appropriate wound caring in 10 patients and by surgical intervention, months later, in 3 patients. According to the final X-ray examination, bone losses caused by local debridement were generally repaired, though the shape of the tibia was not well-restored to its initial form in 17 limbs. No fracture was recorded during follow-up.
conclusionLocal debridement combined with antibiotic-loaded calcium sulfate implantation is effective and safe in a single-stage treatment of chronic Cierny-Mader III tibial osteomyelitis.
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