ArticleParticle and fibre toxicology2020
Urban air particulate matter induces mitochondrial dysfunction in human olfactory mucosal cells.
Article in Particle and fibre toxicology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Multi-omics of oxidative stress and particulate matter exposure: a systematic review.Respiratory research · 2026Pooled it
- Neurobiological mechanisms of olfactory dysfunction: a ten-year bibliometric and visualization analysis.Frontiers in medicine · 2026Pooled it
- Effect of pollution on the prevalence of obesity, diabetic complications and olfactory dysfunction in diabetic patients.Journal of endocrinological investigation · 2026Article
- PMAntioxidants (Basel, Switzerland) · 2026Article
- Loss of Potassium and Chloride Transport Changes PM-Induced Epithelial Dysfunction.Journal of inflammation research · 2026Article
- BKScientific reports · 2025Article
- Ambient Air Pollution and Smell Function: Evidence from the National Geographic Smell Survey.medRxiv : the preprint server for health sciences · 2025Article
- Air pollutants as modulators of mitochondrial quality control in cardiovascular disease.Physiological reports · 2024Review
- Eucalyptus Wood Smoke Extract Elicits a Dose-Dependent Effect in Brain Endothelial Cells.International journal of molecular sciences · 2024Article
- Mitochondrial Dysfunction and Metabolic Reprogramming in Obesity and Asthma.International journal of molecular sciences · 2024Review
- Diesel exhaust particles alter mitochondrial bioenergetics and cAMP producing capacity in human bronchial epithelial cells.Frontiers in toxicology · 2024Article
- Epigenetic mechanisms of particulate matter exposure: air pollution and hazards on human health.Frontiers in genetics · 2023Review
- Aging, longevity, and the role of environmental stressors: a focus on wildfire smoke and air quality.Frontiers in toxicology · 2023Review
- Particulate matter 10 exposure affects intestinal functionality in both inflamed 2D intestinal epithelial cell and 3D intestinal organoid models.Frontiers in immunology · 2023Article
- Environmental Chemical Exposures and Mitochondrial Dysfunction: a Review of Recent Literature.Current environmental health reports · 2022Review
- Associations between urban birth or childhood trauma and first-episode schizophrenia mediated by low IQ.Schizophrenia (Heidelberg, Germany) · 2022Article
- Biometal Dyshomeostasis in Olfactory Mucosa of Alzheimer's Disease Patients.International journal of molecular sciences · 2022Article
- Tryptophan Metabolites Regulate Neuropentraxin 1 Expression in Endothelial Cells.International journal of molecular sciences · 2022Article
- Damage to Olfactory Organs of Adult Zebrafish Induced by Diesel Particulate Matter.International journal of molecular sciences · 2021Article
- TUBE Project: Transport-Derived Ultrafines and the Brain Effects.International journal of environmental research and public health · 2021Article
Corrections and comments
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Authors and funding
16 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe adverse effects of air pollutants including particulate matter (PM) on the central nervous system is increasingly reported by epidemiological, animal and post-mortem studies in the last decade. Oxidative stress and inflammation are key consequences of exposure to PM although little is known of the exact mechanism. The association of PM exposure with deteriorating brain health is speculated to be driven by PM entry via the olfactory system. How air pollutants affect this key entry site remains elusive. In this study, we investigated effects of urban size-segregated PM on a novel cellular model: primary human olfactory mucosal (hOM) cells.
resultsMetabolic activity was reduced following 24-h exposure to PM without evident signs of toxicity. Results from cytometric bead array suggested a mild inflammatory response to PM exposure. We observed increased oxidative stress and caspase-3/7 activity as well as perturbed mitochondrial membrane potential in PM-exposed cells. Mitochondrial dysfunction was further verified by a decrease in mitochondria-dependent respiration. Transient suppression of the mitochondria-targeted gene, neuronal pentraxin 1 (NPTX1), was carried out, after being identified to be up-regulated in PM
conclusionKey mitochondrial functions were perturbed by urban PM exposure in a physiologically relevant cellular model via a mechanism involving NPTX1. In addition, inflammatory response and early signs of apoptosis accompanied mitochondrial dysfunction during exposure to PM. Findings from this study contribute to increased understanding of harmful PM effects on human health and may provide information to support mitigation strategies targeted at air pollution.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.