ArticleJournal of the Royal Society, Interface2020
Physiological silicon incorporation into bone mineral requires orthosilicic acid metabolism to SiO
Article in Journal of the Royal Society, Interface, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Nano-dicalcium silicate promotes angiogenesis via enhancing endothelial cell proliferation, migration and tube formation.Journal of materials science. Materials in medicine · 2026Article
- Application of Amorphous Nanomaterials in Dentistry: A Comprehensive Review.Journal of functional biomaterials · 2025Review
- Microporous Hydroxyapatite-Based Ceramics Alter the Physiology of Endothelial Cells through Physical and Chemical Cues.Journal of functional biomaterials · 2023Article
- Allogenic Stem Cells Carried by Porous Silicon Scaffolds for Active Bone Regeneration In Vivo.Bioengineering (Basel, Switzerland) · 2023Article
- The Influence of Nanosilica on Properties of Cement Based on Tetracalcium Phosphate/Monetite Mixture with Addition of Magnesium Pyrophoshate.Materials (Basel, Switzerland) · 2022Article
- Experimental Testing of the Action of Vitamin D and Silicon Chelates in Bone Fracture Healing and Bone Turnover in Mice and Rats.Nutrients · 2022Article
- Comparison of Biogenic Amorphous Silicas Found in Common Horsetail and Oat Husk With Synthetic Amorphous Silicas.Frontiers in public health · 2022Review
- Biomimicking Bone-Implant Interface Facilitates the Bioadaption of a New Degradable Magnesium Alloy to the Bone Tissue Microenvironment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- A Long Journey of CICA-17 Quinoa Variety to Salinity Conditions in Egypt: Mineral Concentration in the Seeds.Plants (Basel, Switzerland) · 2021Article
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Authors and funding
3 authors.
Funding
Abstract
Under physiological conditions, the predominant form of bioavailable silicon (Si) is orthosilicic acid (OSA). In this study, given Si's recognized positive effect on bone growth and integrity, we examined the chemical form and position of this natural Si source in the inorganic bone mineral hydroxyapatite (HA). X-ray diffraction (XRD) of rat tibia bone mineral showed that the mineral phase was similar to that of phase-pure HA. However, theoretical XRD patterns revealed that at the levels found in bone, the 'Si effect' would be virtually undetectable. Thus we used first principles density functional theory calculations to explore the energetic and geometric consequences of substituting OSA into a large HA model. Formation energy analysis revealed that OSA is not favourable as a neutral interstitial substitution but can be incorporated as a silicate ion substituting for a phosphate ion, suggesting that incorporation will only occur under specific conditions at the bone-remodelling interface and that dietary forms of Si will be metabolized to simpler chemical forms, specifically [Formula: see text]. Furthermore, we show that this substitution, at the low silicate concentrations found in the biological environment, is likely to be a driver of calcium phosphate crystallization from an amorphous to a fully mineralized state.
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