Evidence map›Paper›PMID 32486453›Full record

ArticleCancers2020

Association of a CT-Based Clinical and Radiomics Score of Non-Small Cell Lung Cancer (NSCLC) with Lymph Node Status and Overall Survival.

Francesca Botta, Sara Raimondi, Lisa Rinaldi, Federica Bellerba, Federica Corso, Vincenzo Bagnardi, Daniela Origgi, Rocco Minelli, Giovanna Pitoni, Francesco Petrella and 5 more

Abstract read
In one paragraph

Article in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Francesca BottaMedical Physics, IEO European Institute of Oncology IRCCS, via Ripamonti 435, 20141 Milan, Italy.
Sara RaimondiMolecular and Pharmaco-Epidemiology Unit, Department of Experimental Oncology, IEO European Institute of Oncology IRCCS, via Ripamonti 435, 20141 Milan, Italy.
Lisa RinaldiMedical Physics, IEO European Institute of Oncology IRCCS, via Ripamonti 435, 20141 Milan, Italy.
Federica BellerbaMolecular and Pharmaco-Epidemiology Unit, Department of Experimental Oncology, IEO European Institute of Oncology IRCCS, via Ripamonti 435, 20141 Milan, Italy.
Federica CorsoMolecular and Pharmaco-Epidemiology Unit, Department of Experimental Oncology, IEO European Institute of Oncology IRCCS, via Ripamonti 435, 20141 Milan, Italy.
Vincenzo BagnardiDepartment of Statistics and Quantitative Methods, University of Milano-Bicocca, 20126 Milan, Italy.
Daniela OriggiMedical Physics, IEO European Institute of Oncology IRCCS, via Ripamonti 435, 20141 Milan, Italy.
Rocco MinelliPost-graduate School in Radiodiagnostics, Università degli Studi di Milano, Via Festa del Perdono 7, 20122 Milan, Italy.
Giovanna PitoniPost-graduate School in Radiodiagnostics, Università degli Studi di Milano, Via Festa del Perdono 7, 20122 Milan, Italy.
Francesco PetrellaDepartment of Thoracic Surgery, IEO European Institute of Oncology IRCCS, via Ripamonti 435, 20141 Milan, Italy.ORCID 0000-0001-5945-1576
Lorenzo SpaggiariDepartment of Thoracic Surgery, IEO European Institute of Oncology IRCCS, via Ripamonti 435, 20141 Milan, Italy.
Alessio G MorgantiDepartment of Experimental, Diagnostic and Specialty Medicine-DIMES, University of Bologna, 40126 Bologna, Italy.
Filippo Del GrandeClinica di Radiologia EOC, Istituto Imaging della Svizzera Italiana (IIMSI), Via Tesserete 46, 6900 Lugano, Switzerland.
Massimo BellomiDepartment of Oncology and Hemato-Oncology, Università degli Studi di Milano, 20122 Milan, Italy.
Stefania RizzoDepartment of Experimental, Diagnostic and Specialty Medicine-DIMES, University of Bologna, 40126 Bologna, Italy.ORCID 0000-0002-5151-0866

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo evaluate whether a model based on radiomic and clinical features may be associated with lymph node (LN) status and overall survival (OS) in lung cancer (LC) patients; to evaluate whether CT reconstruction algorithms may influence the model performance.

methodspatients operated on for LC with a pathological stage up to T3N1 were retrospectively selected and divided into training and validation sets. For the prediction of positive LNs and OS, the Least Absolute Shrinkage and Selection Operator (LASSO) logistic regression model was used; univariable and multivariable logistic regression analysis assessed the association of clinical-radiomic variables and endpoints. All tests were repeated after dividing the groups according to the CT reconstruction algorithm.

results270 patients were included and divided into training (n = 180) and validation sets (n = 90). Transfissural extension was significantly associated with positive LNs. For OS prediction, high- and low-risk groups were different according to the radiomics score, also after dividing the two groups according to reconstruction algorithms.

conclusionsa combined clinical-radiomics model was not superior to a single clinical or single radiomics model to predict positive LNs. A radiomics model was able to separate high-risk and low-risk patients for OS; CTs reconstructed with Iterative Reconstructions (IR) algorithm showed the best model performance.

Indexed as

computed tomographylung cancerlymph nodesoverall survivalradiomicsreconstruction algorithms

Identifiers

PMID32486453
PMCPMC7352293

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.