Evidence map›Paper›PMID 32486414›Full record

ArticleMolecules (Basel, Switzerland)2020

Fluctuation Imaging of LRRK2 Reveals that the G2019S Mutation Alters Spatial and Membrane Dynamics.

Bethany J Sanstrum, Brandee M S S Goo, Diana Z Y Holden, Donovan D Delgado, Thien P N Nguyen, Kiana D Lee, Nicholas G James

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Bethany J SanstrumDepartment of Cell and Molecular Biology, University of Hawaii at Manoa, 651 Ilalo Street, Honolulu, HI 96813, USA.ORCID 0000-0002-6313-3383
Brandee M S S GooDepartment of Cell and Molecular Biology, University of Hawaii at Manoa, 651 Ilalo Street, Honolulu, HI 96813, USA.ORCID 0000-0002-9994-6706
Diana Z Y HoldenDepartment of Cell and Molecular Biology, University of Hawaii at Manoa, 651 Ilalo Street, Honolulu, HI 96813, USA.ORCID 0000-0003-0114-640X
Donovan D DelgadoDepartment of Cell and Molecular Biology, University of Hawaii at Manoa, 651 Ilalo Street, Honolulu, HI 96813, USA.ORCID 0000-0002-2165-0702
Thien P N NguyenDepartment of Cell and Molecular Biology, University of Hawaii at Manoa, 651 Ilalo Street, Honolulu, HI 96813, USA.
Kiana D LeeDepartment of Cell and Molecular Biology, University of Hawaii at Manoa, 651 Ilalo Street, Honolulu, HI 96813, USA.
Nicholas G JamesDepartment of Cell and Molecular Biology, University of Hawaii at Manoa, 651 Ilalo Street, Honolulu, HI 96813, USA.
University of Hawaiʻi at Mānoa · US

Funding

TRPA1 Physiology in Diabetes, Metabolic Syndrome, and MetabolismP20GM113134 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI Michael A. Ortega · 2017 to 2026
$21.5M
Michael J. Fox Foundation for Parkinson's Research LRRK2 Pharmacodynamic Assays 2013NIGMS NIH HHS P20 GM113134NIH HHS GM113134-02NIH HHS GM123048-02
6 · The paper itself

Abstract

Mutations within the

Indexed as

EndocytosisMutationAdaptor Proteins, Signal TransducingCell Line, TumorCell MembraneClathrinCytosolFluorescence Resonance Energy TransferGreen Fluorescent ProteinsHumansLeucine-Rich Repeat Serine-Threonine Protein Kinase-2Microscopy, ConfocalParkinson DiseasePhosphorylationProtein DomainsTransferrinAdaptor Proteins, Signal TransducingClathrinGreen Fluorescent ProteinsLeucine-Rich Repeat Serine-Threonine Protein Kinase-2LRRK2 protein, humanSH3GL2 protein, humanTransferrinendocytosisFLIMfluorescence fluctuation spectroscopyFRET-PhasorLRRK2Parkinson’s disease

Identifiers

PMID32486414
PMCPMC7321188
OpenAlexW3031136540

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.