Evidence map›Paper›PMID 32486371›Full record

ArticleNanomaterials (Basel, Switzerland)2020

Functionalization of Single and Multi-Walled Carbon Nanotubes with Polypropylene Glycol Decorated Pyrrole for the Development of Doxorubicin Nano-Conveyors for Cancer Drug Delivery.

Chiara Pennetta, Giuseppe Floresta, Adriana Carol Eleonora Graziano, Venera Cardile, Lucia Rubino, Maurizio Galimberti, Antonio Rescifina, Vincenzina Barbera

Abstract read
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Application of nanoparticles in breast cancer treatment: a systematic review.Naunyn-Schmiedeberg's archives of pharmacology · 2024
    Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Portable Nanocomposite System for Wound Healing in Space.Nanomaterials (Basel, Switzerland) · 2023
    Article
  7. Carbon Nanomaterials for Therapy, Diagnosis and Biosensing.Nanomaterials (Basel, Switzerland) · 2022
    Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chiara PennettaDepartment of Chemistry, Materials and Chemical Engineering "G. Natta", Politecnico di Milano, Via Mancinelli 7, 20131 Milano, Italy.
Giuseppe FlorestaDepartment of Drug Sciences, University of Catania, Viale Andrea Doria 6, 95125 Catania, Italy.ORCID 0000-0002-0668-1260
Adriana Carol Eleonora GrazianoDepartment of Biomedical and Biotechnological Science, Section of Physiology, University of Catania, Via Santa Sofia 97, 95123 Catania, Italy.
Venera CardileDepartment of Biomedical and Biotechnological Science, Section of Physiology, University of Catania, Via Santa Sofia 97, 95123 Catania, Italy.
Lucia RubinoDepartment of Chemistry, Materials and Chemical Engineering "G. Natta", Politecnico di Milano, Via Mancinelli 7, 20131 Milano, Italy.
Maurizio GalimbertiDepartment of Chemistry, Materials and Chemical Engineering "G. Natta", Politecnico di Milano, Via Mancinelli 7, 20131 Milano, Italy.ORCID 0000-0001-5770-7208
Antonio RescifinaDepartment of Drug Sciences, University of Catania, Viale Andrea Doria 6, 95125 Catania, Italy.ORCID 0000-0001-5039-2151
Vincenzina BarberaDepartment of Chemistry, Materials and Chemical Engineering "G. Natta", Politecnico di Milano, Via Mancinelli 7, 20131 Milano, Italy.ORCID 0000-0002-4503-4250

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A recently reported functionalization of single and multi-walled carbon nanotubes, based on a cycloaddition reaction between carbon nanotubes and a pyrrole derived compound, was exploited for the formation of a doxorubicin (DOX) stacked drug delivery system. The obtained supramolecular nano-conveyors were characterized by wide-angle X-ray diffraction (WAXD), thermogravimetric analysis (TGA), high-resolution transmission electron microscopy (HR-TEM), and Fourier transform infrared (FT-IR) spectroscopy. The supramolecular interactions were studied by molecular dynamics simulations and by monitoring the emission and the absorption spectra of DOX. Biological studies revealed that two of the synthesized nano-vectors are effectively able to get the drug into the studied cell lines and also to enhance the cell mortality of DOX at a much lower effective dose. This work reports the facile functionalization of carbon nanotubes exploiting the "pyrrole methodology" for the development of novel technological carbon-based drug delivery systems.

Indexed as

cancercarbon nanotubesdoxorubicindrug delivery systemspyrrole

Identifiers

PMID32486371
PMCPMC7353207

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.