Evidence map›Paper›PMID 32486347›Full record

ReviewCells2020

DNA Methylation Changes in Human Papillomavirus-Driven Head and Neck Cancers.

Chameera Ekanayake Weeramange, Kai Dun Tang, Sarju Vasani, Julian Langton-Lockton, Liz Kenny, Chamindie Punyadeera

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Hypermethylation ofMolecular therapy. Nucleic acids · 2022
    Article
  12. Do or Die: HPV E5, E6 and E7 in Cell Death Evasion.Pathogens (Basel, Switzerland) · 2022
    Review
  13. Review
  14. Review
  15. Review
  16. Role of Virus-Induced Host Cell Epigenetic Changes in Cancer.International journal of molecular sciences · 2021
    Review
  17. Article
  18. Review
  19. Review
  20. DNA Methylation in Solid Tumors: Functions and Methods of Detection.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Chameera Ekanayake WeeramangeQueensland University of Technology (QUT), School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Saliva & Liquid Biopsy Translational Research Team, Queensland 4059, Australia.
Kai Dun TangQueensland University of Technology (QUT), School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Saliva & Liquid Biopsy Translational Research Team, Queensland 4059, Australia.
Sarju VasaniDepartment of Otolaryngology, Royal Brisbane and Women's Hospital, Queensland 4029, Australia.
Julian Langton-LocktonMetro-North Sexual Health and HIV Service, Queensland 4000, Australia.
Liz KennySchool of Medicine, The University of Queensland, Queensland 4006, Australia.
Chamindie PunyadeeraQueensland University of Technology (QUT), School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Saliva & Liquid Biopsy Translational Research Team, Queensland 4059, Australia.
Translational Research Institute · AUMetro South Health · AUQueensland Health · AUThe University of Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Disruption of DNA methylation patterns is one of the hallmarks of cancer. Similar to other cancer types, human papillomavirus (HPV)-driven head and neck cancer (HNC) also reveals alterations in its methylation profile. The intrinsic ability of HPV oncoproteins E6 and E7 to interfere with DNA methyltransferase activity contributes to these methylation changes. There are many genes that have been reported to be differentially methylated in HPV-driven HNC. Some of these genes are involved in major cellular pathways, indicating that DNA methylation, at least in certain instances, may contribute to the development and progression of HPV-driven HNC. Furthermore, the HPV genome itself becomes a target of the cellular DNA methylation machinery. Some of these methylation changes appearing in the viral long control region (LCR) may contribute to uncontrolled oncoprotein expression, leading to carcinogenesis. Consistent with these observations, demethylation therapy appears to have significant effects on HPV-driven HNC. This review article comprehensively summarizes DNA methylation changes and their diagnostic and therapeutic indications in HPV-driven HNC.

Indexed as

AlphapapillomavirusCarcinogenesisDNA MethylationDNA, ViralGenome, ViralHead and Neck NeoplasmsHumansDNA, ViralDNA methylationhead and neck cancerhuman papillomavirus

Identifiers

PMID32486347
PMCPMC7348958
OpenAlexW3031225134

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.