ArticleBrain sciences2020
The Bilateral Ovariectomy in a Female Animal Exacerbates the Pathogenesis of an Intracranial Aneurysm.
Article in Brain sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Characterizing Infiltrating Macrophages in Intracranial Aneurysm with IA Animal Models and Spatial Transcriptomics.Translational stroke research · 2026Review
- Modified Intracranial Aneurysm Rupture Rat Model with Angiographic Imaging.Translational stroke research · 2025Article
- Hypoxic microenvironment as a crucial factor triggering events leading to rupture of intracranial aneurysm.Scientific reports · 2023Article
- The bifurcation angle is associated with the progression of saccular aneurysms.Scientific reports · 2022Article
- Intracranial aneurysm wall (in)stability-current state of knowledge and clinical perspectives.Neurosurgical review · 2022Review
- Integrated analysis identifies the IL6/JAK/STAT signaling pathway and the estrogen response pathway associated with the pathogenesis of intracranial aneurysms.Frontiers in immunology · 2022Article
- Why Are Women Predisposed to Intracranial Aneurysm?Frontiers in cardiovascular medicine · 2022Review
- Experimental and Clinical Treatment of Subarachnoid Hemorrhage after the Rupture of Saccular Intracranial Aneurysms.Brain sciences · 2020Article
- Sex-specific differences in basilar artery vasospasm after subarachnoid hemorrhage: evidence from a rabbit model.Frontiers in neurologyArticle
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
Considering the poor outcome of subarachnoid hemorrhage (SAH) due to the rupture of intracranial aneurysms (IA), mechanisms underlying the pathogenesis of IAs, especially the rupture of lesions, should be clarified. In the present study, a rat model of IAs in which induced lesions spontaneously ruptured resulting in SAH was used. In this model, the combination of the female sex and the bilateral ovariectomy increased the incidence of SAH, similar to epidemiological evidence in human cases. Importantly, unruptured IA lesions induced in female animals with bilateral ovariectomy were histopathologically similar to ruptured ones in the presence of vasa vasorum and the accumulation of abundant inflammatory cells, suggesting the exacerbation of the disease. The post-stenotic dilatation of the carotid artery was disturbed by the bilateral ovariectomy in female rats, which was restored by hormone replacement therapy. The in vivo study thus suggested the protective effect of estrogen from the ovary on endothelial cells loaded by wall shear stress. -estradiol or dihydrotestosterone also suppressed the lipopolysaccharide-induced expression of pro-inflammatory genes in cultured macrophages and neutrophils. The results of the present study have thus provided new insights about the process regulating the progression of the disease.
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Registered trials
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