Evidence map›Paper›PMID 32486316›Full record

ArticleInternational journal of molecular sciences2020

Acetylcholinesterase Inhibition of Diversely Functionalized Quinolinones for Alzheimer's Disease Therapy.

Óscar M Bautista-Aguilera, Lhassane Ismaili, Mourad Chioua, Rudolf Andrys, Monika Schmidt, Petr Bzonek, María Ángeles Martínez-Grau, Christopher D Beadle, Tatiana Vetman, Francisco López-Muñoz and 4 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Óscar M Bautista-AguileraDepartment of Organic Chemistry and Inorganic Chemistry, Alcalá University, Alcalá de Henares, 28805 Madrid, Spain.ORCID 0000-0002-1327-1681
Lhassane IsmailiLaboratoire de Chimie Organique et Thérapeutique, Neurosciences Intégratives et Cliniques EA 481, University Bourgogne Franche-Comté, UFR Santé, 19, rue Ambroise Paré, F-25000 Besançon, France.ORCID 0000-0002-6013-3150
Mourad ChiouaLaboratory of Medicinal Chemistry (IQOG, CSIC), C/ Juan de la Cierva 3, 28006 Madrid, Spain.
Rudolf AndrysDepartment of Chemistry, Faculty of Science, University of Hradec Kralove, Rokitanskeho 62, 500 03 Hradec Kralove, Czech Republic.
Monika SchmidtDepartment of Chemistry, Faculty of Science, University of Hradec Kralove, Rokitanskeho 62, 500 03 Hradec Kralove, Czech Republic.ORCID 0000-0003-4984-9155
Petr BzonekDepartment of Chemistry, Faculty of Science, University of Hradec Kralove, Rokitanskeho 62, 500 03 Hradec Kralove, Czech Republic.ORCID 0000-0001-9651-7917
María Ángeles Martínez-GrauLilly Research Laboratories, Eli Lilly & Company, Avda. de la Industria 30, Alcobendas, 28108 Madrid, Spain.
Christopher D BeadleLilly Research Centre, Eli Lilly & Company, Erl Wood Manor, Windlesham, Surrey GU20 6PH, UK.
Tatiana VetmanLilly Research Laboratories, Eli Lilly & Company, Indianapolis, IN 46285, USA.
Francisco López-MuñozFaculty of Health, Camilo José Cela University of Madrid (UCJC), 28692 Villafranca del Castillo, Spain.ORCID 0000-0002-5188-6038
Isabel IriepaDepartment of Organic Chemistry and Inorganic Chemistry, Alcalá University, Alcalá de Henares, 28805 Madrid, Spain.
Bernard RefouveletLaboratoire de Chimie Organique et Thérapeutique, Neurosciences Intégratives et Cliniques EA 481, University Bourgogne Franche-Comté, UFR Santé, 19, rue Ambroise Paré, F-25000 Besançon, France.
Kamil MusilekDepartment of Chemistry, Faculty of Science, University of Hradec Kralove, Rokitanskeho 62, 500 03 Hradec Kralove, Czech Republic.ORCID 0000-0002-7504-4062
José Marco-ContellesLaboratory of Medicinal Chemistry (IQOG, CSIC), C/ Juan de la Cierva 3, 28006 Madrid, Spain.

Funding

ERDF/ESF CZ.02.1.01/0.0/0.0/16_025/0007444EU COST CA15135 MuTaLigMINECO SAF2015-65586-RUCJC UCJC 2020-03; UCJC 2020-33University of Hradec Kralove SV2113-2019, VT2019-2021
6 · The paper itself

Abstract

In this communication, we report the synthesis and cholinesterase (ChE)/monoamine oxidase (MAO) inhibition of 19 quinolinones (

Indexed as

AcetylcholinesteraseAlzheimer DiseaseCholinesterase InhibitorsDrug DesignDrug Evaluation, PreclinicalHumansInhibitory Concentration 50KineticsLigandsMagnetic Resonance SpectroscopyMolecular Docking SimulationMonoamine OxidaseMonoamine Oxidase InhibitorsQuinolonesRecombinant ProteinsStructure-Activity RelationshipAcetylcholinesteraseCholinesterase InhibitorsLigandsMonoamine Oxidasemonoamine oxidase A, humanMonoamine Oxidase InhibitorsQuinolonesRecombinant ProteinsAlzheimer’s diseaseChE/MAO inhibitioncontilisantdihydroquinolinonesdockingquinolinonessynthesis

Identifiers

PMID32486316
PMCPMC7312762

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.