A Microarray Screening Platform with an Experimental Conditions Gradient Generator for the High-Throughput Synthesis of Micro/Nanosized Calcium Phosphates.

Xiaoyu Li, Zhifeng Shi, Lei Liu, Guanglin Zhu, Jianhua Zhou, Xuetao Shi, Yingjun Wang

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Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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7 authors.

Xiaoyu LiSchool of Materials Science and Engineering, South China University of Technology, Guangzhou 510640, China.

Zhifeng ShiSchool of Materials Science and Engineering, South China University of Technology, Guangzhou 510640, China.

Lei LiuSchool of Materials Science and Engineering, South China University of Technology, Guangzhou 510640, China.

Guanglin ZhuSchool of Materials Science and Engineering, South China University of Technology, Guangzhou 510640, China.

Jianhua ZhouSchool of Biomedical Engineering, Sun Yat-Sen University, Guangzhou 510275, China.ORCID 0000-0001-9895-8679

Xuetao ShiSchool of Materials Science and Engineering, South China University of Technology, Guangzhou 510640, China.

Yingjun WangSchool of Materials Science and Engineering, South China University of Technology, Guangzhou 510640, China.

Funding

National Natural Science Foundation of China 51905557Outstanding Scholar Program of Guangzhou Regenerative Medicine and Health Guangdong Laboratory 2018GZR110102001Science and Technology Program of Guangdong Province 2016A030306018Science and Technology Program of Guangdong Province 2017B090911008Science and Technology Program of Guangdong Province 2019B010941002

6 · The paper itself

Abstract

Calcium phosphates (CaP) represent an impressive kind of biomedical material due to their excellent biocompatibility, bioactivity, and biodegradability. Their morphology and structure highly influence their properties and applications. Whilst great progress has been made in research on biomedical materials, there is still a need to develop a method that can rapidly synthesize and screen micro/nanosized biomedical materials. Here, we utilized a microarray screening platform that could provide the high-throughput synthesis of biomedical materials and screen the vital reaction conditions. With this screening platform, 9 × 9 sets of parallel experiments could be conducted simultaneously with one- or two-dimensions of key reaction condition gradients. We used this platform to establish a one-dimensional gradient of the pH and citrate concentration and a two-dimensional gradient of both the Ca/P ratio and pH to synthesize CaP particles with various morphologies. This screening platform also shows the potential to be extended to other reaction systems for rapid high-throughput screening.

Indexed as

Biocompatible MaterialsCalcium PhosphatesDimethylpolysiloxanesHigh-Throughput Screening AssaysHydrogen-Ion ConcentrationMaterials TestingMicrofluidicsMicroscopy, Electron, ScanningNanoparticlesPolymethyl MethacrylateSpectroscopy, Fourier Transform InfraredX-Ray DiffractionbaysilonBiocompatible Materialscalcium phosphateCalcium PhosphatesDimethylpolysiloxanesPolymethyl Methacrylatecalcium phosphatesconcentration gradienthigh-throughputmicrofluidics

Identifiers

PMID32486293

DOI10.3390/ijms21113939

PMCPMC7312371

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