Evidence map›Paper›PMID 32486135›Full record

ArticleNutrients2020

The Combination of Sulforaphane and Fernblock

Simona Serini, Roberta Guarino, Renata Ottes Vasconcelos, Leonardo Celleno, Gabriella Calviello

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Clinical Applications ofLife (Basel, Switzerland) · 2023
    Review
  10. Article
  11. Uses ofJournal of clinical medicine · 2023
    Article
  12. Role of Phytochemicals in Skin PhotoprotectionFrontiers in pharmacology · 2022
    Review
  13. Improving the Health-Benefits of Kales (Plants (Basel, Switzerland) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Simona SeriniDepartment of Translational Medicine and Surgery, Division of General Pathology, School of Medicine, Università Cattolica del S. Cuore, L.go F. Vito, 1 00168 Rome, Italy.
Roberta GuarinoDepartment of Translational Medicine and Surgery, Division of General Pathology, School of Medicine, Università Cattolica del S. Cuore, L.go F. Vito, 1 00168 Rome, Italy.
Renata Ottes VasconcelosCentro de Investigação Translacional em Oncologia, Laboratório de Oncologia Experimental, Departamento de Radiologia e Oncologia, Instituto do Câncer do Estado de São Paulo, Faculdade de Medicina da Universidade de São Paulo, Dr. Arnaldo Avenue, 251-Cerqueira César, São Paulo 01246000, Brazil.
Leonardo CellenoFondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli, 8 00168 Rome, Italy.
Gabriella CalvielloDepartment of Translational Medicine and Surgery, Division of General Pathology, School of Medicine, Università Cattolica del S. Cuore, L.go F. Vito, 1 00168 Rome, Italy.
Agostino Gemelli University Polyclinic · ITUniversità Cattolica del Sacro Cuore · ITInstituto do Câncer do Estado de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plenty of evidence supports the health effects exerted by dietary supplements containing phytochemicals, but the actual efficacy and safety of their combinations have been seldom experimentally evaluated. On this basis, we investigated in vitro the antioxidant/antineoplastic efficacy and anti-aging activity of a dietary supplement containing sulforaphane (SFN), a sulfur-isothiocyanate present in broccoli, combined with the patented extract Fernblock

Indexed as

Antineoplastic AgentsAntioxidantsBrassicaCell Line, TumorCell MovementHumansInflammasomesInterleukin-1betaIsothiocyanatesKeratinocytesMatrix MetalloproteinasesMelanomaNLR Family, Pyrin Domain-Containing 3 ProteinPlant ExtractsSkinSkin AgingAntineoplastic AgentsAntioxidantsfernblockInflammasomesInterleukin-1betaIsothiocyanatesisothiocyanic acidMatrix MetalloproteinasesNLR Family, Pyrin Domain-Containing 3 ProteinNLRP3 protein, humanPlant ExtractssulforaphaneSulfoxidesantioxidantFernblock® XPinvasionkeratinocytesmelanoma cellsmetalloproteinasesmigrationsulforaphane

Identifiers

PMID32486135
PMCPMC7353001
OpenAlexW3029593200

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.