Evidence map›Paper›PMID 32486059›Full record

ArticleAntibiotics (Basel, Switzerland)2020

Adapting a Phage to Combat Phage Resistance.

Elina Laanto, Kati Mäkelä, Ville Hoikkala, Janne J Ravantti, Lotta-Riina Sundberg

Abstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Carbapenem Resistance inMicroorganisms · 2025
    Review
  9. Review
  10. Frontiers in cellular and infection microbiology · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Does Phage Therapy Need a Pan-Phage?Pathogens (Basel, Switzerland) · 2024
    Review
  16. Article
  17. Overcoming Bacteriophage Resistance in Phage Therapy.Methods in molecular biology (Clifton, N.J.) · 2024
    Review
  18. Phage Therapy-Challenges, Opportunities and Future Prospects.Pharmaceuticals (Basel, Switzerland) · 2023
    Review
  19. Article
  20. PHAGE (New Rochelle, N.Y.) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Elina LaantoFaculty of Biological and Environmental Sciences, Molecular and Integrative Biosciences Research Programme, University of Helsinki, 00014 Helsinki, Finland.
Kati MäkeläDepartment of Biological and Environmental Science, Nanoscience Center, University of Jyvaskyla, 40014 Jyvaskyla, Finland.
Ville HoikkalaDepartment of Biological and Environmental Science, Nanoscience Center, University of Jyvaskyla, 40014 Jyvaskyla, Finland.
Janne J RavanttiFaculty of Biological and Environmental Sciences, Molecular and Integrative Biosciences Research Programme, University of Helsinki, 00014 Helsinki, Finland.
Lotta-Riina SundbergDepartment of Biological and Environmental Science, Nanoscience Center, University of Jyvaskyla, 40014 Jyvaskyla, Finland.

Funding

Academy of Finland 314939Academy of Finland 321985
6 · The paper itself

Abstract

Phage therapy is becoming a widely recognized alternative for fighting pathogenic bacteria due to increasing antibiotic resistance problems. However, one of the common concerns related to the use of phages is the evolution of bacterial resistance against the phages, putatively disabling the treatment. Experimental adaptation of the phage (phage training) to infect a resistant host has been used to combat this problem. Yet, there is very little information on the trade-offs of phage infectivity and host range. Here we co-cultured a myophage FCV-1 with its host, the fish pathogen

Indexed as

coevolutionfish pathogenphage resistancephage therapy

Identifiers

PMID32486059
PMCPMC7345892

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.