Evidence map›Paper›PMID 32486023›Full record

ArticleInternational journal of molecular sciences2020

Healthspan Enhancement by Olive Polyphenols in

Gabriele Di Rosa, Giovanni Brunetti, Maria Scuto, Angela Trovato Salinaro, Edward J Calabrese, Roberto Crea, Christian Schmitz-Linneweber, Vittorio Calabrese, Nadine Saul

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 1 pooled it
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 1 synthesis or guideline pooled it, 112 citations in OpenAlex.

  1. Pooled it
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  12. The Extract ofCurrent neuropharmacology · 2025
    Article
  13. Studying the mechanisms of neurodegeneration:Frontiers in cellular neuroscience · 2025
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  15. Research Progress on Neural Cell Culture Systems.Current neuropharmacology · 2025
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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Gabriele Di RosaDepartment of Biomedical and Biotechnological Sciences, University of Catania, 95125 Catania, Italy.
Giovanni BrunettiDepartment of Biomedical and Biotechnological Sciences, University of Catania, 95125 Catania, Italy.
Maria ScutoDepartment of Biomedical and Biotechnological Sciences, University of Catania, 95125 Catania, Italy.
Angela Trovato SalinaroDepartment of Biomedical and Biotechnological Sciences, University of Catania, 95125 Catania, Italy.ORCID 0000-0003-2377-858X
Edward J CalabreseDepartment of Environmental Health Sciences, Morrill I, N344, University of Massachusetts, Amherst, MA 01003, USA.
Roberto CreaOliphenol LLC., 26225 Eden Landing Road, Unit C, Hayward, CA 94545, USA.
Christian Schmitz-LinneweberFaculty of Life Sciences, Institute of Biology, Molecular Genetics Group, Humboldt University of Berlin, Philippstr. 13, House 22, 10115 Berlin, Germany.
Vittorio CalabreseDepartment of Biomedical and Biotechnological Sciences, University of Catania, 95125 Catania, Italy.ORCID 0000-0002-0478-985X
Nadine SaulFaculty of Life Sciences, Institute of Biology, Molecular Genetics Group, Humboldt University of Berlin, Philippstr. 13, House 22, 10115 Berlin, Germany.ORCID 0000-0002-6798-0918
University of Catania · ITHumboldt-Universität zu Berlin · DEUniversity of Massachusetts Amherst · US

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
NIH HHS P40 OD010440
6 · The paper itself

Abstract

Parkinson's disease (PD) is the second most prevalent late-age onset neurodegenerative disorder, affecting 1% of the population after the age of about 60 years old and 4% of those over 80 years old, causing motor impairments and cognitive dysfunction. Increasing evidence indicates that Mediterranean diet (MD) exerts beneficial effects in maintaining health, especially during ageing and by the prevention of neurodegenerative disorders. In this regard, olive oil and its biophenolic constituents like hydroxytyrosol (HT) have received growing attention in the past years. Thus, in the current study we test the health-promoting effects of two hydroxytyrosol preparations, pure HT and Hidrox

Indexed as

Agingalpha-SynucleinAnimalsAnimals, Genetically ModifiedBiomarkersCaenorhabditis elegansCaenorhabditis elegans ProteinsDiet, MediterraneanDisease Models, AnimalDopaminergic NeuronsHumansLongevityMicroscopy, FluorescenceOleaOlive OilParkinson Diseasealpha-SynucleinBiomarkersCaenorhabditis elegans ProteinsOlive OilPolyphenolsRotenoneSNCA protein, humanageingC. eleganshealthspanlifespanolive oilParkinson’s diseasepolyphenols

Identifiers

PMID32486023
PMCPMC7312680
OpenAlexW3029697541

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.